首页> Cancer letters> Gain of chromosome 17 is an early genetic abnormality in neuroblastoma with PPM1D emerging as a strong candidate oncogene driving tumor progression.

Gain of chromosome 17 is an early genetic abnormality in neuroblastoma with PPM1D emerging as a strong candidate oncogene driving tumor progression.

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第一作者： Jelena,Milosevic

第一单位： Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, United States. Electronic address: JMILOSEVIC@mgh.harvard.edu.

作者： Jelena,Milosevic ^[1] ; Susanne,Fransson ^[2] ; Johanna,Svensson ^[2] ; Jörg,Otte ^[3] ; Thale K,Olsen ^[4] ; Baldur,Sveinbjornsson ^[3] ; Falk,Hertwig ^[5] ; Christoph,Bartenhagen ^[5] ; Frida,Abel ^[2] ; Susanne E,Reinsbach ^[2] ; Anna,Djos ^[2] ; Niloufar,Javanmardi ^[2] ; Yao,Shi ^[6] ; Jane Y,Hehir-Kwa ^[7] ; Arjen,Mensenkamp ^[8] ; Godelieve Am,Tytgat ^[7] ; Johan,Holmberg ^[9] ; Jan J,Molenaar ^[10] ; Marjolijn,Jongmans ^[7] ; Matthias,Fischer ^[5] ; Ninib,Baryawno ^[3] ; David,Gisselsson ^[11] ; Tommy,Martinsson ^[2] ; Per,Kogner ^[3] ; John Inge,Johnsen ^[12]

作者单位： Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, United States. Electronic address: JMILOSEVIC@mgh.harvard.edu. ^[1] Department of Laboratory Medicine, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden. ^[2] Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden. ^[3] Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden. ^[4] Department of Experimental Pediatric Oncology, University Children's Hospital, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne, Cologne, Germany. ^[5] Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden. ^[6] Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands. ^[7] Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands. ^[8] Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden; Department of Molecular Biology, Umeå University, Umeå, Sweden. ^[9] Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Department of Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands. ^[10] Division of Clinical Genetics, Faculty of Medicine, Lund University, Lund, Sweden; Section for Pathology, Department of Clinical Genetics, Pathology and Molecular Diagnostics, Office of Medical Services, Region Skåne, Sweden. ^[11] Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden. Electronic address: john.inge.johnsen@ki.se. ^[12]

关键词 Chromosome 17q Neuroblastoma PPM1D WIP1 p53