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Muscadine Grape Skin Extract in Biochemically Recurrent Prostate Cancer: A Randomized, Placebo-Controlled, Biomarker-Enriched Trial in Patients With the SOD2 Ala/Ala Variant.

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第一作者： A,Mandl

第一单位： Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins, Baltimore, MD, USA.

作者： A,Mandl ^[1] ; M L,Zahurak ^[1] ; N A,Metri ^[1] ; N D,Shore ^[2] ; S,Mao ^[3] ; R R,McKay ^[4] ; M E,Taplin ^[5] ; R Z,Szmulewitz ^[6] ; B L,Maughan ^[7] ; Z R,Reichert ^[8] ; E R,Kessler ^[9] ; E I,Heath ^[10] ; R,Dreicer ^[11] ; C A,Stein ^[12] ; G L,Milne ^[13] ; K S,Sfanos ^[14] ; S E,Ernst ^[15] ; L A,Mummert ^[15] ; A,Cruz-Lebrón ^[15] ; S L J,Michel ^[16] ; M A,Kane ^[16] ; M,Hursey ^[16] ; M A,Worth ^[16] ; W D,Wagner ^[17] ; J R,Eshleman ^[1] ; M,Debeljak ^[1] ; L,Xu ^[1] ; H,Cao ^[1] ; D,Dowling ^[1] ; C H,Marshall ^[1] ; M C,Markowski ^[1] ; S R,Denmeade ^[1] ; M A,Eisenberger ^[1] ; E S,Antonarakis ^[18] ; M A,Carducci ^[1] ; C J,Paller ^[1]

作者单位： Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins, Baltimore, MD, USA. ^[1] Carolina Urologic Research Center, Myrtle Beach, SC, USA. ^[2] Allegheny Health Network, Pittsburgh, PA, USA. ^[3] University of California, San Diego, La Jolla, CA, USA. ^[4] Dana-Farber Cancer Institute, Boston, MA, USA. ^[5] University of Chicago Medical Center, Chicago, IL, USA. ^[6] Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT, USA. ^[7] University of Michigan Medical School, Ann Arbor, MI, USA. ^[8] University of Colorado Cancer Center, Anschutz Medical Campus, Aurora, CO, USA. ^[9] Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA. ^[10] University of Virginia School of Medicine, Charlottesville, VA, USA. ^[11] City of Hope Medical Center, Madras, OR, USA. ^[12] Vanderbilt University Medical Center, Nashville, TN, USA. ^[13] Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins, Baltimore, MD, USA.;Johns Hopkins University School of Medicine, Baltimore, MD, USA. ^[14] Johns Hopkins University School of Medicine, Baltimore, MD, USA. ^[15] University of Maryland, College Park, MD, USA. ^[16] Wake Forest University School of Medicine, Winston-Salem, NC, USA.;Muscadine Naturals Inc., Clemmons, NC, USA. ^[17] University of Minnesota, Masonic Cancer Center, Minneapolis, MN, USA. ^[18]

关键词 biochemical recurrence genetic biomarker manganese superoxide dismutase muscadine grape skin extract prostate cancer randomized controlled clinical trial