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A pathway toward clinical translation of hyperpolarized [1,4-13C2,2,3-d2]fumarate as an imaging biomarker for early cellular necrosis in vivo.

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第一作者： Jonathan R,Birchall

第一单位： Department of Radiology, University of Cambridge, Cambridge, UK.

作者： Jonathan R,Birchall ^[1] ; Pascal,Wodtke ^[2] ; Ashley,Grimmer ^[2] ; Esben S S,Hansen ^[3] ; Lotte B,Bertelsen ^[3] ; Nikolaj,Bøgh ^[3] ; Marta,Wylot ^[1] ; Maria J,Zamora-Morales ^[1] ; Otso,Arponen ^[4] ; Ines,Horvat-Menih ^[1] ; Elizabeth C,Latimer ^[1] ; Fung,Tan ^[5] ; Evita,Pappa ^[6] ; Johann,Graggaber ^[7] ; Joseph,Cheriyan ^[8] ; Kelly,Holmes ^[9] ; Matthew J,Locke ^[1] ; Helen,Sladen ^[9] ; Joan,Boren ^[10] ; Mikko I,Kettunen ^[11] ; Anita,Chhabra ^[5] ; Ian B,Wilkinson ^[8] ; Christoffer,Laustsen ^[3] ; Kevin,Brindle ^[12] ; Mary A,McLean ^[13] ; Ferdia A,Gallagher ^[2]

作者单位： Department of Radiology, University of Cambridge, Cambridge, UK. ^[1] Department of Radiology, University of Cambridge, Cambridge, UK.;Cancer Research UK Cambridge Centre, Cambridge, UK. ^[2] Department of Clinical Medicine, Aarhus University MR Research Centre, Aarhus, Denmark. ^[3] Department of Radiology, University of Cambridge, Cambridge, UK.;Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland. ^[4] Radiopharmacy Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. ^[5] Division of Experimental Medicine and Immunotherapeutics, Department of Medicine, University of Cambridge, Cambridge, UK. ^[6] Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. ^[7] Division of Experimental Medicine and Immunotherapeutics, Department of Medicine, University of Cambridge, Cambridge, UK.;Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. ^[8] Cancer Research UK Cambridge Centre, Cambridge, UK. ^[9] The Discovery Centre, AstraZeneca, Cambridge Biomedical Campus, Cambridge, UK. ^[10] A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.;Cancer Research UK Cambridge Institute, Cambridge, UK. ^[11] Cancer Research UK Cambridge Centre, Cambridge, UK.;Cancer Research UK Cambridge Institute, Cambridge, UK. ^[12] Department of Radiology, University of Cambridge, Cambridge, UK.;Cancer Research UK Cambridge Centre, Cambridge, UK.;Cancer Research UK Cambridge Institute, Cambridge, UK. ^[13]

关键词 HP 13C‐MRI clinical translation hyperpolarization imaging biomarker necrosis preclinical