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Beyond CEN.PK - parallel engineering of selected S. cerevisiae strains reveals that superior chassis strains require different engineering approaches for limonene production.

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第一作者： Yanmei,Zhu

第一单位： VIB - KU Leuven Center for Microbiology, Gaston Geenslaan 1, 3001, Leuven, Belgium; CMPG Laboratory of Genetics and Genomics, Department M2S, KU Leuven, Gaston Geenslaan 1, 3001, Leuven, Belgium.

作者： Yanmei,Zhu ^[1] ; Sasha,Yogiswara ^[1] ; Anke,Willekens ^[1] ; Agathe,Gérardin ^[1] ; Rob,Lavigne ^[2] ; Alain,Goossens ^[3] ; Vitor B,Pinheiro ^[4] ; Zongjie,Dai ^[5] ; Kevin J,Verstrepen ^[6]

作者单位： VIB - KU Leuven Center for Microbiology, Gaston Geenslaan 1, 3001, Leuven, Belgium; CMPG Laboratory of Genetics and Genomics, Department M2S, KU Leuven, Gaston Geenslaan 1, 3001, Leuven, Belgium. ^[1] Laboratory of Gene Technology, KU Leuven, Kasteelpark Arenberg 21 box 2462, Heverlee, 3001, Leuven, Belgium. ^[2] Department of Plant Biotechnology and Bioinformatics, Ghent University, B-9052 Ghent, Belgium; VIB Center for Plant Systems Biology, B-9052 Ghent, Belgium; Department of Botany and Zoology, Stellenbosch University, Private Bag X1, Matieland, 7600, South Africa. ^[3] KU Leuven, Rega Institute for Medical Research, Department of Pharmaceutical and Pharmacological Sciences, Herestraat, 49 - box 1041, 3000, Leuven, Belgium. ^[4] Key Laboratory of Engineering Biology for Low-carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. Electronic address: daizj@tib.cas.cn. ^[5] VIB - KU Leuven Center for Microbiology, Gaston Geenslaan 1, 3001, Leuven, Belgium; CMPG Laboratory of Genetics and Genomics, Department M2S, KU Leuven, Gaston Geenslaan 1, 3001, Leuven, Belgium. Electronic address: kevin.verstrepen@kuleuven.be. ^[6]

关键词 Chassis strain Limonene Mevalonate pathway Microbial cell factory Precision fermentation Saccharomyces cerevisiae

医学主题词酿酒酵母菌(Saccharomyces cerevisiae)

DOI 10.1016/j.ymben.2025.04.011

PMID 40334774

发布时间 2025-07-16

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