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Promoting Secretion of Pathological Tau Species Using an Induced Proximity Platform That Engages the Autophagy Pathway.

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第一作者： Yekaterina,Kovalyova

第一单位： Neuroscience, Merck & Co., Inc., West Point, Pennsylvania 19486, United States.

作者： Yekaterina,Kovalyova ^[1] ; Cesar,De Leon ^[2] ; Alicja,Krasowska-Zoladek ^[1] ; Sokreine,Suon ^[1] ; Jacky,Wong ^[1] ; Seth,Young ^[3] ; Julien,Lee Heberling ^[3] ; Laura,Price ^[4] ; Raphaëlle,Berger ^[5] ; Brian,Magliaro ^[4] ; Yu-Shan,Cheng ^[6] ; Andrea,Peier ^[6] ; Deborah M,Rothman ^[3] ; Abbas,Walji ^[7] ; Sean,Smith ^[1] ; Jacob,Marcus ^[1] ; Xiaoqing,Han ^[3] ; Marija,Usenovic ^[1]

作者单位： Neuroscience, Merck & Co., Inc., West Point, Pennsylvania 19486, United States. ^[1] Chemical Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States. ^[2] Chemical Biology, Merck & Co., Inc., Rahway, New Jersey 07065, United States. ^[3] Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States. ^[4] Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States. ^[5] Quantitative Biosciences, Merck & Co., Inc., Rahway, New Jersey 07065, United States. ^[6] Discovery Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, United States. ^[7]

关键词 aggregates autophagy neurodegenerative diseases secretion targeted protein degradation tau

医学主题词自噬(Autophagy);tau蛋白质类(tau Proteins);人类(Humans);溶酶体(Lysosomes);动物(Animals);磷酰化(Phosphorylation);神经元(Neurons)

DOI 10.1021/acschemneuro.5c00161

PMID 40344401

发布时间 2025-05-21

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准确一般字义偏差语意偏离译文作用小提交