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A novel TRKB-activating internal tandem duplication characterizes a new mechanism of receptor tyrosine kinase activation.

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第一作者： Lauren M,Brown

第一单位： Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.;School of Clinical Medicine, UNSW Sydney, Sydney, NSW, Australia.

作者： Lauren M,Brown ^[1] ; Gabor,Tax ^[1] ; Pablo,Acera Mateos ^[1] ; Antoine,de Weck ^[1] ; Steve,Foresto ^[2] ; Thomas,Robertson ^[2] ; Fatimah,Jalud ^[3] ; Pamela,Ajuyah ^[4] ; Paulette,Barahona ^[4] ; Jie,Mao ^[4] ; M Emmy M,Dolman ^[1] ; Marie,Wong ^[1] ; Chelsea,Mayoh ^[1] ; Mark J,Cowley ^[1] ; Loretta M S,Lau ^[5] ; Teresa,Sadras ^[3] ; Paul G,Ekert ^[6]

作者单位： Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.;School of Clinical Medicine, UNSW Sydney, Sydney, NSW, Australia. ^[1] Queensland Children's Hospital, Brisbane, QLD, Australia. ^[2] Peter MacCallum Cancer Centre, Parkville, VIC, Australia.;The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia. ^[3] Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia. ^[4] Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia.;School of Clinical Medicine, UNSW Sydney, Sydney, NSW, Australia.;Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia. ^[5] Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia. pekert@ccia.org.au.;School of Clinical Medicine, UNSW Sydney, Sydney, NSW, Australia. pekert@ccia.org.au.;Peter MacCallum Cancer Centre, Parkville, VIC, Australia. pekert@ccia.org.au.;The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia. pekert@ccia.org.au.;University of New South Wales Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia. pekert@ccia.org.au. ^[6]

DOI 10.1038/s41698-025-00928-3

PMID 40348911

发布时间 2025-05-13

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NPJ precision oncology

2025年9卷1期

137页

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NPJ precision oncology

2025年9卷1期

137页

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A novel TRKB-activating internal tandem duplication characterizes a new mechanism of receptor tyrosine kinase activation.

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A novel TRKB-activating internal tandem duplication characterizes a new mechanism of receptor tyrosine kinase activation.

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