Lipopolysaccharide-induced DNA damage response activates DNA-PKcs to drive actin cytoskeleton disruption and cardiac microvascular dysfunction in endotoxemia.
第一作者:
Ying,Tan
第一单位:
Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.;Department of Critical Care Medicine, The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China.
作者:
医学主题词
动物(Animals);人类(Humans);脂多糖类(Lipopolysaccharides);小鼠(Mice);DNA损伤(DNA Damage);DNA活化蛋白激酶(DNA-Activated Protein Kinase);内毒素血症(Endotoxemia);男(雄)性(Male);微血管(Microvessels);疾病模型, 动物(Disease Models, Animal);小鼠, 近交C57BL(Mice, Inbred C57BL);脓毒症(Sepsis);内皮细胞(Endothelial Cells);心肌疾病(Cardiomyopathies)
DOI
10.7150/thno.111266
PMID
40365284
发布时间
2025-05-15
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Theranostics
5969-5997页
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