首页> Journal of experimental & clinical cancer research : CR> HBV-driven host chromatin accessibility changes affect liver metabolic pathways, iron homeostasis and promote a preneoplastic phenotype.

HBV-driven host chromatin accessibility changes affect liver metabolic pathways, iron homeostasis and promote a preneoplastic phenotype.

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第一作者： Vincenzo,Alfano

第一单位： IHU EVEREST - Institut of Hepatology Lyon, UMR UCLB1 INSERM U1350 PaThLiv, 69004, Lyon, France.;INSERM U1052, Cancer Research Center of Lyon (CRCL), Lyon, France.

作者： Vincenzo,Alfano ^[1] ; Giuseppe Rubens,Pascucci ^[2] ; Giacomo,Corleone ^[3] ; Massimiliano,Cocca ^[4] ; Francesca,De Nicola ^[3] ; Océane,Floriot ^[5] ; Alexia,Paturel ^[6] ; Francesca Casuscelli,Di Tocco ^[5] ; Claude Caron,de Fromentel ^[4] ; Philippe,Merle ^[7] ; Michel,Rivoire ^[8] ; Massimo,Levrero ^[9] ; Francesca,Guerrieri ^[10]

作者单位： IHU EVEREST - Institut of Hepatology Lyon, UMR UCLB1 INSERM U1350 PaThLiv, 69004, Lyon, France.;INSERM U1052, Cancer Research Center of Lyon (CRCL), Lyon, France. ^[1] Research Unit of Clinical Immunology and Vaccinology, Bambino Gesù Children's Hospital, 00165, Rome, Italy.;Center for Life Nano Science (CNLS), Istituto Italiano Di Tecnologia (IIT), 00161, Rome, Italy. ^[2] SAFU Laboratory, Department of Research, Advanced Diagnostics, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, 00144, Rome, Italy. ^[3] IHU EVEREST - Institut of Hepatology Lyon, UMR UCLB1 INSERM U1350 PaThLiv, 69004, Lyon, France. ^[4] INSERM U1052, Cancer Research Center of Lyon (CRCL), Lyon, France. ^[5] IHU EVEREST - Institut of Hepatology Lyon, UMR UCLB1 INSERM U1350 PaThLiv, 69004, Lyon, France.;Université Catholique de Lyon (UCLy), 69002, Lyon, France. ^[6] IHU EVEREST - Institut of Hepatology Lyon, UMR UCLB1 INSERM U1350 PaThLiv, 69004, Lyon, France.;Department of Hepatology, Croix Rousse Hospital, Hospices Civils de Lyon, 69004, Lyon, France. ^[7] INSERM U1052, Centre de Lutte Contre Le Cancer Léon Bérard (CLB), 69003, Lyon, France. ^[8] IHU EVEREST - Institut of Hepatology Lyon, UMR UCLB1 INSERM U1350 PaThLiv, 69004, Lyon, France. massimo.levrero@inserm.fr.;Department of Hepatology, Croix Rousse Hospital, Hospices Civils de Lyon, 69004, Lyon, France. massimo.levrero@inserm.fr. ^[9] IHU EVEREST - Institut of Hepatology Lyon, UMR UCLB1 INSERM U1350 PaThLiv, 69004, Lyon, France. francesca.guerrieri@inserm.fr. ^[10]

关键词 ATAC-seq Chromatin remodeling HBV-related HCC Iron uptake RNA-seq