首页> European journal of medicinal chemistry> Design, synthesis, and biological evaluation of C-12 modified ocotillol-type derivatives as novel P-glycoprotein modulators for overcoming multidrug resistance.

Design, synthesis, and biological evaluation of C-12 modified ocotillol-type derivatives as novel P-glycoprotein modulators for overcoming multidrug resistance.

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第一作者： Cheng,Chen

第一单位： School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China.

作者： Cheng,Chen ^[1] ; Ziqian,Hao ^[1] ; Jiaxuan,Chen ^[1] ; Shuang,Li ^[1] ; Yongyuan,Su ^[1] ; Suwei,Jiang ^[1] ; Lin,Ma ^[1] ; Hanqi,Lv ^[1] ; Xinjie,Pei ^[1] ; Peng,Zhang ^[1] ; Hongbo,Wang ^[1] ; Gangqiang,Yang ^[2]

作者单位： School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China. ^[1] School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, 264005, China. Electronic address: oceanygq@ytu.edu.cn. ^[2]

关键词 Multidrug resistance Ocotillol-type derivatives P-glycoprotein Structure-activity relationship