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Combining high-throughput ASD screening with the rDCS to streamline development of poorly soluble drugs.

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第一作者： Malte Bøgh,Senniksen

第一单位： Fraunhofer Institute for Translational Medicine and Pharmacology, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany; Pharmaceutical R&D, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland.

作者： Malte Bøgh,Senniksen ^[1] ; Nicole,Wyttenbach ^[2] ; Susanne,Page ^[3] ; Jennifer,Dressman ^[4]

作者单位： Fraunhofer Institute for Translational Medicine and Pharmacology, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany; Pharmaceutical R&D, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland. ^[1] Pharmaceutical Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland. ^[2] Pharmaceutical R&D, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland. ^[3] Fraunhofer Institute for Translational Medicine and Pharmacology, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany. Electronic address: jdresssman@em.uni-frankfurt.de. ^[4]

关键词 Amorphous solid dispersion Dissolution High-throughput screening Oral absorption Refined developability classification system (rDCS)Supersaturation