首页> Bioengineering & translational medicine> Establishing a scalable perfusion strategy for the manufacture of CAR-T cells in stirred-tank bioreactors using a quality-by-design approach.

Establishing a scalable perfusion strategy for the manufacture of CAR-T cells in stirred-tank bioreactors using a quality-by-design approach.

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第一作者： Tiffany,Hood

第一单位： Department of Biochemical Engineering University College London London UK.

作者： Tiffany,Hood ^[1] ; Pierre,Springuel ^[1] ; Fern,Slingsby ^[2] ; Viktor,Sandner ^[3] ; Winfried,Geis ^[4] ; Timo,Schmidberger ^[4] ; Nicola,Bevan ^[5] ; Quentin,Vicard ^[6] ; Julia,Hengst ^[7] ; Noushin,Dianat ^[6] ; Qasim A,Rafiq ^[1]

作者单位： Department of Biochemical Engineering University College London London UK. ^[1] Product Excellence Bioreactor Technology Sartorius Stedim UK Limited Epsom UK. ^[2] Digital Solutions Sartorius Stedim Austria GmbH Vienna Austria. ^[3] Digital Solutions Sartorius Stedim Biotech GmbH Goettingen Germany. ^[4] BioAnalytics Application Development Essen BioScience Ltd. (part of the Sartorius Group) Royston UK. ^[5] Cell Culture Technology Marketing Sartorius Stedim France S.A.S. Aubagne France. ^[6] Cell Culture Technology Marketing, Sartorius Stedim Biotech GmbH, Goettingen, Germany. ^[7]

关键词 CAR‐T perfusion, immunotherapy process control process intensification quality‐by‐design stirred‐tank bioreactor

DOI 10.1002/btm2.10753

PMID 40385527

发布时间 2025-05-20

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Establishing a scalable perfusion strategy for the manufacture of CAR-T cells in stirred-tank bioreactors using a quality-by-design approach.

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Establishing a scalable perfusion strategy for the manufacture of CAR-T cells in stirred-tank bioreactors using a quality-by-design approach.

Bioengineering & translational medicine

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