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Antitumor activity of rucaparib plus PLX038A in serous endometrial carcinoma.

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第一作者： Xiaonan,Hou

第一单位： Division of Medical Oncology, Mayo Clinic, Rochester, MN, 55905, USA.

作者： Xiaonan,Hou ^[1] ; Valentina,Zanfagnin ^[1] ; Conway,Xu ^[2] ; Erik,Jessen ^[3] ; Yuanhang,Liu ^[3] ; Chen,Wang ^[4] ; Yajue,Huang ^[5] ; Shaun D,Fontaine ^[6] ; Daniel V,Santi ^[6] ; Gerardo,Colon-Otero ^[7] ; Sarah E,Gill ^[8] ; Gretchen E,Glaser ^[8] ; Kristina A,Butler ^[9] ; Jamie N,Bakkum-Gamez ^[8] ; Sean C,Dowdy ^[8] ; Ann L,Oberg ^[10] ; Melissa C,Larson ^[11] ; Hunter J,Atkinson ^[11] ; Laura N,Duffield ^[12] ; Kevin L,Peterson ^[12] ; Scott H,Kaufmann ^[13] ; S John,Weroha ^[14]

作者单位： Division of Medical Oncology, Mayo Clinic, Rochester, MN, 55905, USA. ^[1] Division of Medical Oncology, Mayo Clinic, Rochester, MN, 55905, USA.;Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Mayo Clinic, MN, 55905, USA. ^[2] Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA. ^[3] Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 55905, USA.;Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, 55905, USA. ^[4] Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA. ^[5] ProLynx LLC, 455 Mission Bay Blvd, South San Francisco, CA, 94158, USA. ^[6] Hematology/Oncology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA. ^[7] Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Mayo Clinic, MN, 55905, USA. ^[8] Medical & Surgical Gynecology Department, Mayo Clinic, Phoenix, AZ, USA. ^[9] Department of Quantitative Health Sciences, Division of Computational Biology, Mayo Clinic, Rochester, MN, 55905, USA. ^[10] Department of Quantitative Health Sciences, Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN, 55905, USA. ^[11] Division of Oncology Research, Mayo Clinic, Rochester, MN, 55905, USA. ^[12] Division of Oncology Research, Mayo Clinic, Rochester, MN, 55905, USA.;Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, 55905, USA. ^[13] Division of Medical Oncology, Mayo Clinic, Rochester, MN, 55905, USA. Weroha.Saravut@mayo.edu.;Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, 55905, USA. Weroha.Saravut@mayo.edu.;Department of Oncology, Mayo Clinic College of Medicine, 200 First St. SW, Rochester, MN, 55905, USA. Weroha.Saravut@mayo.edu. ^[14]

关键词 DNA repair Endometrial cancer Homologous recombination PARP inhibitor Rucaparib SN-38 Xenografts