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Optimized GMP-grade production of non-viral Sleeping Beauty-generated CARCIK cells for enhanced fitness and clinical scalability.

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第一作者： Ilaria,Pisani

第一单位： Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

作者： Ilaria,Pisani ^[1] ; Giusi,Melita ^[1] ; Patricia Borges,de Souza ^[2] ; Stefania,Galimberti ^[3] ; Angela Maria,Savino ^[4] ; Jolanda,Sarno ^[4] ; Beatrice,Landoni ^[1] ; Stefano,Crippa ^[1] ; Elisa,Gotti ^[5] ; Carolina,Cuofano ^[5] ; Olga,Pedrini ^[5] ; Chiara,Capelli ^[5] ; Giada,Matera ^[6] ; Daniela,Belotti ^[6] ; Stefania,Cesana ^[6] ; Benedetta,Cabiati ^[6] ; Michele,Quaroni ^[6] ; Valentina,Colombo ^[6] ; Massimiliano,Mazza ^[2] ; Barbara,Vergani ^[4] ; Anna,Gaimari ^[2] ; Fabio,Nicolini ^[2] ; Marcella,Tazzari ^[2] ; Martine,Bocchini ^[2] ; Marta,Serafini ^[7] ; Alessandro,Rambaldi ^[8] ; Benedetta,Rambaldi ^[9] ; Giuseppe,Dastoli ^[1] ; Andrea,Biondi ^[1] ; Giuseppe,Gaipa ^[10] ; Martino,Introna ^[5] ; Josée,Golay ^[5] ; Sarah,Tettamanti ^[1]

作者单位： Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy. ^[1] Advanced Cellular Therapies and Rare Tumors Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" S.r.l., Meldola, Italy. ^[2] Bicocca Bioinformatics Biostatistics and Bioimaging B4 Center, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy. ^[3] Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy. ^[4] Center of Cellular Therapy "G. Lanzani", Division of Hematology, ASST Papa Giovanni XXIII, Bergamo, 24122, Italy. ^[5] Laboratorio di Terapia Cellulare e Genica Stefano Verri, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy. ^[6] Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.;Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy. ^[7] Department of Oncology and Hematology, University of Milan, Milan, Italy.;Department of Oncology-Hematology, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy. ^[8] Department of Oncology-Hematology, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy. ^[9] Tettamanti Center, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy. giuseppe.gaipa@irccs-sangerardo.it. ^[10]

关键词 CAR T cells Good manufacturing practices (GMP)Hematological malignancies Sleeping beauty transposon T cell fitness Workflow optimization