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GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration.

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第一作者： Dan Pascal Jean,Albers

第一单位： Institute of Molecular Virology, Ulm University Medical Center, 89081, Ulm, Germany.

作者： Dan Pascal Jean,Albers ^[1] ; Sofya,Novikova ^[1] ; Julio,Vieyto-Nuñez ^[2] ; Yasser,Almeida-Hernández ^[2] ; Chiara,Pastorio ^[1] ; Florian,Klassen ^[1] ; Dana,Weiss ^[1] ; Pascal,von Maltitz ^[1] ; Janeni,Jaikishan ^[3] ; Moumita,Datta ^[3] ; Hassan,Jumaa ^[3] ; Billy Michael Chelliah,Jebaraj ^[4] ; Stephan,Stilgenbauer ^[4] ; Manish,Kumar ^[5] ; Palash Chandra,Maity ^[5] ; Christian,Buske ^[5] ; Ulrich,Stifel ^[6] ; Julia,Zinngrebe ^[6] ; Pamela,Fischer-Posovszky ^[7] ; Andy,Chevigné ^[8] ; Frank,Kirchhoff ^[1] ; Elsa,Sanchez-Garcia ^[2] ; Jan,Münch ^[1] ; Mirja,Harms ^[9]

作者单位： Institute of Molecular Virology, Ulm University Medical Center, 89081, Ulm, Germany. ^[1] Chair of Computational Bioengineering, Department of Biochemical and Chemical Engineering, Technical University Dortmund, 44227, Dortmund, Germany. ^[2] Institute of Immunology, Ulm University Medical Center, 89081, Ulm, Germany. ^[3] Division of CLL, Department of Internal Medicine III, Ulm University Medical Center, 89081, Ulm, Germany. ^[4] Institute of Experimental Cancer Research, Ulm University Medical Center, 89081, Ulm, Germany. ^[5] Department of Pediatrics and Adolescent Medicine, University Medical Center, Ulm, Germany. ^[6] Department of Pediatrics and Adolescent Medicine, University Medical Center, Ulm, Germany.;German Center for Child and Adolescent Health (DZKJ), partner site Ulm, Ulm, Germany. ^[7] Immuno-Pharmacology and Interactomics, Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg. ^[8] Institute of Molecular Virology, Ulm University Medical Center, 89081, Ulm, Germany. Mirja.Harms@uni-ulm.de. ^[9]

关键词 CXCR4 signaling Cancer metastasis GPR15LG Immune cell migration Wound healing