首页> ACS catalysis> α-Hydrazino Acids Inhibit Pyridoxal Phosphate-Dependent Decarboxylases via "Catalytically Correct" Ketoenamine Tautomers: A Special Motif for Chemical Biology and Drug Discovery?

α-Hydrazino Acids Inhibit Pyridoxal Phosphate-Dependent Decarboxylases via "Catalytically Correct" Ketoenamine Tautomers: A Special Motif for Chemical Biology and Drug Discovery?

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第一作者： Jonathan M,Baine

第一单位： Department of Chemistry, University of Nebraska, Lincoln, Nebraska 68588, United States.

作者： Jonathan M,Baine ^[1] ; Yoan,Duhoo ^[2] ; Tzanko,Doukov ^[3] ; Ambroise,Desfosses ^[2] ; Giovanni,Bisello ^[4] ; Matthew L,Beio ^[1] ; Olivia,Bauer ^[5] ; Massimiliano,Perduca ^[4] ; Maria,Bacia-Verloop ^[2] ; Mariarita,Bertoldi ^[4] ; Robert S,Phillips ^[5] ; Irina,Gutsche ^[6] ; David B,Berkowitz ^[1]

作者单位： Department of Chemistry, University of Nebraska, Lincoln, Nebraska 68588, United States. ^[1] 1 Univ. Grenoble Alpes, CEA, CNRS, IBS, F-38000 Grenoble, France. ^[2] Stanford Synchrotron Radiation Lightsource, Stanford University, Menlo Park, California 94025, United States. ^[3] Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy. ^[4] Departments of Chemistry and Biochemistry, University of Georgia, Athens, Georgia 30602, United States. ^[5] 1 Univ. Grenoble Alpes, CEA, CNRS, IBS, F-38000 Grenoble, France.;Department of Chemistry, Umeå University, SE-901 87 Umeå, Sweden. ^[6]

DOI 10.1021/acscatal.5c00326

PMID 40401103

发布时间 2026-05-03

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准确一般字义偏差语意偏离译文作用小提交