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Epigallocatechin-3-gallate binds tandem RNA recognition motifs of TDP-43 and inhibits its aggregation.

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第一作者： Maria Agnese,Morando

第一单位： Structural Biology and Biophysics Unit, Fondazione Ri.MED, 90133, Palermo, Italy.

作者： Maria Agnese,Morando ^[1] ; Vito,D'Alessandro ^[2] ; Angelo,Spinello ^[3] ; Martina,Sollazzo ^[4] ; Elisa,Monaca ^[1] ; Raffaele,Sabbatella ^[1] ; Maria Concetta,Volpe ^[5] ; Francesca,Gervaso ^[6] ; Alessandro,Polini ^[6] ; Sarah,Mizielinska ^[7] ; Caterina,Alfano ^[8]

作者单位： Structural Biology and Biophysics Unit, Fondazione Ri.MED, 90133, Palermo, Italy. ^[1] Structural Biology and Biophysics Unit, Fondazione Ri.MED, 90133, Palermo, Italy.;Department of Mathematics and Physics "E. De Giorgi", University of Salento, 73100, Lecce, Italy. ^[2] Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90028, Palermo, Italy. ^[3] Structural Biology and Biophysics Unit, Fondazione Ri.MED, 90133, Palermo, Italy.;Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, 90028, Palermo, Italy. ^[4] Fondazione Ri.MED, 90133, Palermo, Italy. ^[5] CNR Nanotec-Institute of Nanotechnology, Campus Ecotekne, 73100, Lecce, Italy. ^[6] UK Dementia Research Institute at King's College London, London, UK.;Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. ^[7] Structural Biology and Biophysics Unit, Fondazione Ri.MED, 90133, Palermo, Italy. calfano@fondazionerimed.com. ^[8]

关键词 ALS EGCG stability Protein aggregation Protein-ligand interaction RNA-binding proteins TDP-43

医学主题词儿茶素(Catechin);DNA结合蛋白质类(DNA-Binding Proteins);人类(Humans);蛋白质结合(Protein Binding);肌萎缩侧索硬化(Amyotrophic Lateral Sclerosis)

DOI 10.1038/s41598-025-02035-6

PMID 40404809

发布时间 2025-05-25

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