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Targeting METTL3 protein by proteolysis-targeting chimeras: A novel therapeutic approach for acute myeloid leukemia.

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第一作者： Rukiye,Nar

第一单位： Department of Medicine, UF Health Cancer Center, University of Florida, Gainesville, FL 32610, USA.;Department of Medicine, and Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, USA.

作者： Rukiye,Nar ^[1] ; Zhixing,Wu ^[2] ; Yafang,Li ^[1] ; Alexis,Smith ^[2] ; Yutao,Zhang ^[3] ; Jue,Wang ^[1] ; Fang,Yu ^[1] ; Sanhui,Gao ^[1] ; Chunjie,Yu ^[1] ; Zhiguang,Huo ^[3] ; Guangrong,Zheng ^[2] ; Zhijian,Qian ^[1]

作者单位： Department of Medicine, UF Health Cancer Center, University of Florida, Gainesville, FL 32610, USA.;Department of Medicine, and Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610, USA. ^[1] Department of Medicinal Chemistry, University of Florida, Gainesville, FL 32610, USA. ^[2] Department of Biostatistics, University of Florida, Gainesville, FL 32610, USA. ^[3]

关键词 Acute myeloid leukemia METTL3 PROTAC Protein degradation ZW27941

DOI 10.1016/j.gendis.2024.101452

PMID 40453361

发布时间 2025-06-03

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Targeting METTL3 protein by proteolysis-targeting chimeras: A novel therapeutic approach for acute myeloid leukemia.

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Targeting METTL3 protein by proteolysis-targeting chimeras: A novel therapeutic approach for acute myeloid leukemia.

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