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Low-Dose Methotrexate for the Treatment of Inflammatory Knee Osteoarthritis: A Randomized Clinical Trial.

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第一作者: Zhaohua,Zhu
第一单位: Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.;Sydney Musculoskeletal Health and Royal North Shore Hospital, Kolling Institute, University of Sydney, Sydney, Australia.
作者: Zhaohua,Zhu [1] ; Qinghong,Yu [2] ; Xiaomei,Leng [3] ; Jianhua,Xu [4] ; Limin,Ren [5] ; Kun,Wang [6] ; Cibo,Huang [7] ; Yunfeng,Pan [8] ; Yi,Zhao [9] ; Tianwang,Li [10] ; Yifang,Mei [11] ; Meihua,Guan [12] ; Xiaoxia,Li [9] ; Zhiyi,Zhang [13] ; Jing,Wu [2] ; Yingjuan,Chen [7] ; Yuan,Qu [2] ; Xiaotong,Zhu [2] ; Qiuju,Liao [9] ; Zhe,Wang [6] ; Zetao,Liao [8] ; Yang,Xi [11] ; Weiming,Deng [10] ; Kang,Wang [4] ; Tingting,Zhu [4] ; Yuping,Zhang [2] ; Lixia,Gao [12] ; Xiaoni,Zhou [14] ; Weiyu,Han [15] ; Guangfeng,Ruan [16] ; Yan,Zhang [14] ; Peihua,Cao [14] ; Peichun,Gao [14] ; Haowei,Chen [14] ; Qin,Dang [14] ; Flavia M,Cicuttini [17] ; David J,Hunter [1] ; Zhanguo,Li [5] ; Xiaofeng,Zeng [3] ; Changhai,Ding [18]
作者单位: Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.;Sydney Musculoskeletal Health and Royal North Shore Hospital, Kolling Institute, University of Sydney, Sydney, Australia. [1] Department of Rheumatology and Clinical Immunology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. [2] Department of Rheumatology and Clinical Immunology, Peking Union Medical Collage Hospital, Chinese Academy of Medical Science; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. [3] Department of Rheumatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. [4] Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China. [5] Department of Joint and Trauma Surgery, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. [6] Department of Rheumatology, Beijing Hospital Affiliated to the National Health Commission, Beijing, China. [7] Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. [8] Department of Rheumatology & Allergy, Xuanwu Hospital of Capital Medical University, Beijing, China. [9] Department of Rheumatology, Guangdong Second People's Hospital, Guangzhou, China. [10] Department of Rheumatology, Shenzhen Third People's Hospital, Shenzhen, China. [11] Department of Rheumatology, Central People's Hospital of Zhanjiang, Zhanjiang, China. [12] Department of Rheumatology, The First Affiliated Hospital of Harbin Medical University, Harbin, China. [13] Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. [14] Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.;Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. [15] Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.;Clinical Research Centre, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China. [16] Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia. [17] Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.;Clinical Research Centre, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.;Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia. [18]
DOI 10.1001/jamainternmed.2025.1359
PMID 40455462
发布时间 2026-02-06
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JAMA internal medicine

JAMA internal medicine

2025年185卷7期

808-816页

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