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Rifampicin combination therapy versus targeted antimicrobial monotherapy in the oral antimicrobial treatment phase of staphylococcal prosthetic joint infection (RiCOTTA-trial): protocol for a randomized, controlled, open-label, non-inferiority trial.

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第一作者: Jaap L J,Hanssen
第一单位: Leiden University Center for Infectious Diseases (LU-CID), Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: j.l.j.hanssen@lumc.nl.
作者单位: Leiden University Center for Infectious Diseases (LU-CID), Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: j.l.j.hanssen@lumc.nl. [1] Leiden University Center for Infectious Diseases (LU-CID), Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands. [2] Department of Orthopaedic and Sports Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands. [3] Department of Orthopaedic Surgery, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands. [4] Department of Internal Medicine, Isala Clinics, Zwolle, The Netherlands. [5] Department of Orthopaedic Surgery, Alrijne Hospital, Leiderdorp, The Netherlands. [6] Department of Orthopaedic Surgery, Spaarne Gasthuis, Hoofddorp, the Netherlands and Department of Oral Cell Biology, Academic Centre for Dentistry (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. [7] Department of Internal Medicine, Section of Infectious Diseases, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Movement Sciences, Rehabilitation and Development, Amsterdam, The Netherlands; Amsterdam Institute for Infection and Immunity Institute, Infectious Diseases, Amsterdam, The Netherlands. [8] Department of Orthopaedic Surgery, OLVG, Amsterdam, the Netherlands and Department of Orthopaedic Surgery, Leiden University Medical Center, Leiden, The Netherlands. [9] Department of Orthopaedic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands. [10] Department of Orthopaedic Surgery, Rijnstate Hospital, Arnhem, The Netherlands. [11] Department of Orthopaedic Surgery, Sint Maartenskliniek, Nijmegen, The Netherlands and Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands. [12] Department of Orthopaedic Surgery, Reinier Haga Orthopaedic Center, Zoetermeer, The Netherlands. [13] Department of Internal Medicine, Martini Hospital, Groningen, The Netherlands. [14] Department of Orthopaedic Surgery, Medical Centre Leeuwarden, Leeuwarden, The Netherlands. [15] Department of Orthopaedic Surgery, Amphia Hospital, Breda, The Netherlands. [16] Department of Orthopaedic Surgery, Maastricht University Medical Center, Maastricht, The Netherlands. [17] Department of Orthopaedic Surgery, Gelre Hospital, Apeldoorn, The Netherlands. [18] Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, Groningen, The Netherlands. [19] Leiden University Center for Infectious Diseases (LU-CID), Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. [20]
DOI 10.1016/j.cct.2025.107972
PMID 40456484
发布时间 2025-07-31
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