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Gene-Environment Interaction Affects Risk of Atopic Eczema: Population and In Vitro Studies.

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第一作者: Marie,Standl
第一单位: Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.;German Center for Child and Adolescent Health (DZKJ), partner site Munich, Munich, Germany.
作者: Marie,Standl [1] ; Ashley,Budu-Aggrey [2] ; Luke J,Johnston [3] ; Martina S,Elias [3] ; S Hasan,Arshad [4] ; Peter,Bager [5] ; Veronique,Bataille [6] ; Helena,Blakeway [2] ; Klaus,Bønnelykke [7] ; Dorret,Boomsma [8] ; Ben M,Brumpton [9] ; Mariona,Bustamante Pineda [10] ; Archie,Campbell [3] ; John A,Curtin [11] ; Anders,Eliasen [7] ; João P S,Fadista [5] ; Bjarke,Feenstra [5] ; Trine,Gerner [12] ; Carolina,Medina-Gomez [13] ; Sarah,Grosche [14] ; Kristine B,Gutzkow [15] ; Anne-Sofie,Halling [16] ; Caroline,Hayward [3] ; John,Henderson [2] ; Esther,Herrera-Luis [17] ; John W,Holloway [18] ; Joukejan,Hottenga [8] ; Jonathan,O'B Hourihane [19] ; Chen,Hu [20] ; Kristian,Hveem [21] ; Amaia,Irizar [22] ; Bénédicte,Jacquemin [23] ; Leon,Jessen [7] ; Sara,Kress [24] ; Ramesh J,Kurukulaaratchy [4] ; Susanne,Lau [25] ; Sabrina,Llop [26] ; Mari,Løset [27] ; Ingo,Marenholz [28] ; Dan,Mason [29] ; Daniel L,McCartney [3] ; Mads,Melbye [30] ; Erik,Melén [31] ; Camelia,Minica [8] ; Clare S,Murray [11] ; Tamar,Nijsten [32] ; Luba M,Pardo [32] ; Suzanne,Pasmans [32] ; Craig E,Pennell [33] ; Maria R,Rinnov [34] ; Gillian,Santorelli [29] ; Tamara,Schikowski [24] ; Darina,Sheehan [35] ; Angela,Simpson [11] ; Cilla,Söderhäll [36] ; Laurent F,Thomas [37] ; Jacob P,Thyssen [16] ; Maties,Torrent [38] ; Toos,van Beijsterveldt [8] ; Alessia,Visconti [39] ; Judith M,Vonk [40] ; Carol A,Wang [33] ; Cheng-Jian,Xu [41] ; Ali H,Ziyab [42] ; UK Translational Research Network in Dermatology [43] ; BIOMAP Consortium [44] ; Adnan,Custovic [45] ; Paola,Di Meglio [46] ; Liesbeth,Duijts [47] ; Carsten,Flohr [48] ; Alan D,Irvine [49] ; Gerard H,Koppelman [50] ; Young-Ae,Lee [44] ; Nick J,Reynolds [51] ; Catherine,Smith [52] ; Sinéad M,Langan [53] ; Lavinia,Paternoster ; Sara J,Brown
作者单位: Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.;German Center for Child and Adolescent Health (DZKJ), partner site Munich, Munich, Germany. [1] MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK. [2] Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. [3] Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.;NIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, UK.;Asthma and Allergy Research Centre, Isle of Wight, UK. [4] Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark. [5] Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. [6] COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. [7] Department of Biological Psychology, Faculty of Behavioral and Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands. [8] Department of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway. [9] ISGlobal, Institute for Global Health, Barcelona, Spain.;Universitat Pompeu Fabra (UPF), Barcelona, Spain.;Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain. [10] Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, UK. [11] Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark. [12] Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. [13] Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany. [14] Division of Climate and Environmental Health, Department of Air Quality and Noise, Norwegian Institute of Public Health (NIPH), Oslo, Norway. [15] Department of Dermatology and Venereology, Bispebjerg Hospital, University of Copenhagen, Copenhagen N, Denmark. [16] Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA. [17] NIHR Southampton Biomedical Research Centre, University Hospitals Southampton NHS Foundation Trust, Southampton, UK.;Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK. [18] Royal College of Surgeons in Ireland, Dublin, Ireland.;Children's Health Ireland, Dublin, Ireland.;INFANT Centre, University College Cork, Cork, Ireland. [19] The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.;Department of Dermatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. [20] Department of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.;Department for Research, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. [21] Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.;Department of Preventive Medicine and Public Health, UPV/EHU, Leioa, Spain.;Biogipuzkoa HRI, Donostia, Spain. [22] Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, Rennes, France. [23] IUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany. [24] Department of Pediatric Respiratory Medicine, Immunology, and Intensive Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany. [25] Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.;Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain. [26] Department of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.;Department of Dermatology, Clinic of Orthopedy, Rheumatology and Dermatology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. [27] Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.;Clinic for Pediatric Allergy, Experimental and Clinical Research Center, Charité University Medical Center, Berlin, Germany. [28] Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK. [29] Danish Cancer Institute, Copenhagen, Denmark.;Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.;Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA. [30] Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden. [31] Department of Dermatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. [32] School of Medicine and Public Health, The University of Newcastle, Newcastle, New South Wales, Australia.;Mothers and Babies Research Program, Hunter Medical Research Institute, Newcastle, New South Wales, Australia. [33] Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.;Department of Neonatology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. [34] INFANT Centre, University College Cork, Cork, Ireland.;University College Cork, Cork, Ireland.;Cork University Hospital, Cork, Ireland. [35] Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.;Astrid Lindgren's Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. [36] Department of Public Health and Nursing, HUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.;Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.;BioCore - Bioinformatics Core Facility, Norwegian University of Science and Technology, Trondheim, Norway. [37] Area de Salut de Menorca, ib-salut, Balearic Islands, Spain. [38] Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.;Department of Clinical and Biological Sciences, Center for Biostatistics, Epidemiology and Public Health, University of Turin, Turin, Italy. [39] Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.;University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, the Netherlands. [40] Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz Centre for Infection Research (HZI) and Hannover Medical School (MHH), Hannover, Germany.;TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany. [41] Department of Community Medicine and Behavioral Sciences, College of Medicine, Kuwait University, Kuwait City, Kuwait. [42] National Heart and Lung Institute, Imperial College London, London, UK. [43] St John's Institute of Dermatology and the School of Basic and Medical Sciences, King's College London, London, UK. [44] Division of Respiratory Medicine and Allergology, and Neonatology, Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.;Division of Neonatology, Department of Neonatal and Intensive Care, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. [45] Department of Paediatric Dermatology, St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK. [46] Department of Clinical Medicine, Trinity College Dublin, Dublin, Ireland. [47] University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, the Netherlands.;Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. [48] Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.;Department of Pediatric Respiratory Medicine, Immunology, and Intensive Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.;Clinic for Pediatric Allergy, Experimental and Clinical Research Center, Charité University Medical Center, Berlin, Germany. [49] Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.;Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. [50] Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.;St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, UK. [51] MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.;NIHR Bristol Biomedical Research Centre, University Hospital Bristol and Weston NHS Foundation Trust and University of Bristol, Bristol, UK. [52] Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.;Department of Dermatology, NHS Lothian, Edinburgh, Scotland, UK. [53]
DOI 10.1111/all.16605
PMID 40462597
发布时间 2025-09-16
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