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Enrichment of Full AAV2 Using Multicolumn Countercurrent Solvent Gradient Purification (MCSGP).

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第一作者： Julia M,Müller

第一单位： Institute of Pharma Technology and Biotechnology, University of Applied Sciences and Arts Northwestern Switzerland, Muttenz, Switzerland.;Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

作者： Julia M,Müller ^[1] ; Tereza,Müllerová ^[2] ; Daniela,Tobler ^[2] ; Damian,Hauri ^[2] ; Richard,Plieninger ^[2] ; Yuki,Higuchi ^[3] ; Ryosuke,Takahashi ^[3] ; Sebastian,Vogg ^[4] ; Thomas,Müller-Späth ^[4] ; Thomas K,Villiger ^[2]

作者单位： Institute of Pharma Technology and Biotechnology, University of Applied Sciences and Arts Northwestern Switzerland, Muttenz, Switzerland.;Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. ^[1] Institute of Pharma Technology and Biotechnology, University of Applied Sciences and Arts Northwestern Switzerland, Muttenz, Switzerland. ^[2] YMC CO., LTD., Kyoto, Japan. ^[3] ChromaCon AG, Zürich, Switzerland. ^[4]

关键词 AAV adeno‐associated virus anion exchange chromatography continuous purification full/empty separation multicolumn countercurrent solvent gradient purification (MCSGP)

医学主题词依赖病毒(Dependovirus);反流分布法(Countercurrent Distribution);人类(Humans);病毒壳体(Capsid);溶剂(Solvents)

DOI 10.1002/bit.29036

PMID 40468522

发布时间 2025-08-05

基金项目

::This study was supported by ChromaCon AG and YMC CO., LTD.::

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准确一般字义偏差语意偏离译文作用小提交