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In vivo labeling reveals that degranulation is increased under supraphysiological TCR stimulation, but not infection, in CD8<sup>+</sup> T cells from old mice.

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第一作者： Korbyn J V,Dahlquist

第一单位： Biochemistry, Molecular Biology, and Biophysics Graduate Program, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.;Masonic Institute On the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.;Center for Immunology, University of Minnesota, Minneapolis, MN, USA.

作者： Korbyn J V,Dahlquist ^[1] ; Emma M,Dehm ^[2] ; Declan M,Smith ^[3] ; Erin D,Lucas ^[4] ; Mark,Pierson ^[4] ; Sara E,Hamilton ^[4] ; Christina D,Camell ^[5]

作者单位： Biochemistry, Molecular Biology, and Biophysics Graduate Program, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.;Masonic Institute On the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.;Center for Immunology, University of Minnesota, Minneapolis, MN, USA. ^[1] Masonic Institute On the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.;Center for Immunology, University of Minnesota, Minneapolis, MN, USA.;Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota Medical School, Minneapolis, MN, USA. ^[2] Masonic Institute On the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA. ^[3] Center for Immunology, University of Minnesota, Minneapolis, MN, USA.;Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA. ^[4] Biochemistry, Molecular Biology, and Biophysics Graduate Program, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA. ccamell@umn.edu.;Masonic Institute On the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA. ccamell@umn.edu.;Center for Immunology, University of Minnesota, Minneapolis, MN, USA. ccamell@umn.edu. ^[5]

关键词 Aging CD8+ T cells Cytotoxicity Degranulation Infection

医学主题词动物(Animals);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);细胞脱颗粒(Cell Degranulation);小鼠(Mice);衰老(Aging);受体, 抗原, T细胞(Receptors, Antigen, T-Cell);小鼠, 近交C57BL(Mice, Inbred C57BL)

DOI 10.1007/s11357-025-01723-5

PMID 40478430

发布时间 2026-05-24

基金项目

P01 AI172501/AI/NIAID NIH HHS/United States P01AI172501/National Institute of Health (NIH) R01AG079913/National Institute of Health (NIH) T32AG029796/National Institute of Health (NIH) R21AG078638/National Institute of Health (NIH)

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In vivo labeling reveals that degranulation is increased under supraphysiological TCR stimulation, but not infection, in CD8<sup>+</sup> T cells from old mice.

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In vivo labeling reveals that degranulation is increased under supraphysiological TCR stimulation, but not infection, in CD8<sup>+</sup> T cells from old mice.

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