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GSK3α negatively regulates GSK3β by decreasing its protein levels and enzymatic activity in mouse embryonic stem cells.

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第一作者： Duo,Wang

第一单位： Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: duow@usc.edu.

作者： Duo,Wang ^[1] ; Xi,Chen ^[2] ; Joshua,Feng ^[3] ; Xueyuan A,Jing ^[4] ; Jiaqi,Tang ^[3] ; Jean Paul,Chadarevian ^[4] ; Haeyoung,Park ^[4] ; Matthew,Lee ^[4] ; Fan,Feng ^[4] ; Chao,Zhang ^[3] ; Qi-Long,Ying ^[5]

作者单位： Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: duow@usc.edu. ^[1] Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: xichen@caltech.edu. ^[2] Loker Hydrocarbon Research Institute & Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA. ^[3] Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. ^[4] Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: qying@med.usc.edu. ^[5]

关键词 AKT signaling GSK3α GSK3β mouse embryonic stem cells neural differentiation protein degradation stem cell self-renewal

医学主题词动物(Animals);小鼠(Mice);糖原合成酶激酶3(Glycogen Synthase Kinase 3);细胞分化(Cell Differentiation);蛋白质结合(Protein Binding)

DOI 10.1016/j.stemcr.2025.102512

PMID 40480219

发布时间 2026-05-05

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