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Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A.

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第一作者: Charlotte K,Brierley
第一单位: Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM) and NIHR Biomedical Research Centre, University of Oxford, Oxford, UK. charlotte.brierley@imm.ox.ac.uk.;Computational Oncology Service, Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. charlotte.brierley@imm.ox.ac.uk.;Department of Haematology, OUH NHS Foundation Trust, Oxford, UK. charlotte.brierley@imm.ox.ac.uk.
作者单位: Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM) and NIHR Biomedical Research Centre, University of Oxford, Oxford, UK. charlotte.brierley@imm.ox.ac.uk.;Computational Oncology Service, Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. charlotte.brierley@imm.ox.ac.uk.;Department of Haematology, OUH NHS Foundation Trust, Oxford, UK. charlotte.brierley@imm.ox.ac.uk. [1] Division of Experimental Haematology, St Jude Children's Research Hospital, Memphis, TN, USA. [2] Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM) and NIHR Biomedical Research Centre, University of Oxford, Oxford, UK. [3] Ludwig Institute for Cancer Research Brussels, Brussels, Belgium.;de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.;Walloon Excellence in Life Sciences and Biotechnology (WELBIO) Department, WEL Research Institute, Wavre, Belgium.;Ludwig Institute for Cancer Research, Nuffield Department of Medicine, Oxford University, Oxford, UK. [4] Isabl Inc., New York, NY, USA. [5] Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.;Christie Hospital, The Christie NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. [6] Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK. [7] Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM) and NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.;Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. [8] The Hub for Biotechnology in the Built Environment, Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK. [9] Department of Haematology, OUH NHS Foundation Trust, Oxford, UK. [10] Oxford Regional Genetics Laboratories, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. [11] Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.;Experimental and Clinical Research Center (ECRC) of the MDC and Charité Berlin, Berlin, Germany. [12] Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM) and NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.;Department of Haematology, Guys and St Thomas' NHS Foundation Trust, London, UK. [13] Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, TN, USA.;Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA. [14] Wolfson Childhood Cancer Research Centre, Newcastle University, Newcastle upon Tyne, UK. [15] Department of Haematology, Guys and St Thomas' NHS Foundation Trust, London, UK. [16] Department of Haematology, Beatson West of Scotland Cancer Centre, Glasgow, UK. [17] Division of Cancer & Genetics, School of Medicine, Cardiff University, Cardiff, UK. [18] Division of Hematology, Mayo Clinic, Rochester, MN, USA. [19] INSERM, UMR 1287, Villejuif, France.;Gustave Roussy, Villejuif, France.;Université Paris Saclay, Gif-sur-Yvette, France. [20] Computational Oncology Service, Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.;Isabl Inc., New York, NY, USA. [21] Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM) and NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.;Department of Haematology, OUH NHS Foundation Trust, Oxford, UK.;Ludwig Institute for Cancer Research, Nuffield Department of Medicine, Oxford University, Oxford, UK. [22] Division of Experimental Haematology, St Jude Children's Research Hospital, Memphis, TN, USA. john.crispino@stjude.org. [23] Medical Research Council (MRC) Weatherall Institute of Molecular Medicine (WIMM) and NIHR Biomedical Research Centre, University of Oxford, Oxford, UK. adam.mead@imm.ox.ac.uk.;Department of Haematology, OUH NHS Foundation Trust, Oxford, UK. adam.mead@imm.ox.ac.uk. [24]
DOI 10.1038/s41588-025-02190-6
PMID 40490510
发布时间 2025-08-01
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