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Uncovering codon usage patterns during murine embryogenesis and tissue-specific developmental diseases.

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第一作者： Sarah E,Fumagalli

第一单位： Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Silver Spring, MD, United States.

作者： Sarah E,Fumagalli ^[1] ; Sean,Smith ^[2] ; Brian,Lin ^[1] ; Rahul,Paul ^[2] ; Collin,Campbell ^[2] ; Luis,Santana-Quintero ^[2] ; Anton,Golikov ^[2] ; Juan,Ibla ^[3] ; Haim,Bar ^[4] ; Anton A,Komar ^[5] ; Ryan C,Hunt ^[1] ; Michael,DiCuccio ^[6] ; Chava,Kimchi-Sarfaty ^[1]

作者单位： Hemostasis Branch, Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Silver Spring, MD, United States. ^[1] High-performance Integrated Virtual Environment (HIVE), Office of Biostatistics and Pharmacovigilance (OBPV), Center for Biologics Evaluation and Research (CBER), US Food and Drug Administration (FDA), Silver Spring, MD, United States. ^[2] Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, United States. ^[3] Department of Statistics, University of Connecticut, Storrs, CT, United States. ^[4] Center for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, OH, United States.;Department of Biochemistry and Center for RNA Science and Therapeutics, School of Medicine, Case Western Reserve University, Cleveland, OH, United States. ^[5] Independent Researcher, Rockville, MD, United States. ^[6]

关键词 clustering methods disease-associated comparison machine learning mouse embryology relative synonymous codon usage tissue-specific transcriptomic-weighted

DOI 10.3389/fgene.2025.1554773

PMID 40491567

发布时间 2025-06-11

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