首页> The Journal of clinical endocrinology and metabolism> No More Free Lunch: Challenges to Mendelian Randomization Due to Sample Selection and Complex Methods.

No More Free Lunch: Challenges to Mendelian Randomization Due to Sample Selection and Complex Methods.

导出 OA

翻译打印收藏纠错

第一作者： Tianyuan,Lu

第一单位： Department of Population Health Sciences, University of Wisconsin-Madison, Madison, WI 53726, USA.;Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53726, USA.;Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, WI 53706, USA.;Center for Genomic Science Innovation, University of Wisconsin-Madison, Madison, WI 53706, USA.;Center for Human Genomics and Precision Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.

作者： Tianyuan,Lu ^[1] ; Wenmin,Zhang ^[2] ; Fergus W,Hamilton ^[3] ; Guillaume,Butler-Laporte ^[4] ; Nicholas J,Timpson ^[5] ; George,Davey Smith ^[6] ; J Brent,Richards ^[7]

作者单位： Department of Population Health Sciences, University of Wisconsin-Madison, Madison, WI 53726, USA.;Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53726, USA.;Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, WI 53706, USA.;Center for Genomic Science Innovation, University of Wisconsin-Madison, Madison, WI 53706, USA.;Center for Human Genomics and Precision Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA. ^[1] Montreal Heart Institute, University of Montreal, Montreal, QC H1T 1C8, Canada. ^[2] MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.;Infection Science, North Bristol NHS Trust, Bristol BS10 5NB, UK. ^[3] Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada.;Division of Infectious Diseases, McGill University Health Centre, Montreal, QC H4A 0B1, Canada. ^[4] MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.;Department of Population Health Sciences, University of Bristol, Bristol BS8 2PS, UK. ^[5] MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK. ^[6] Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada.;Department of Human Genetics, McGill University, Montreal, QC H3A 0G4, Canada.;Department of Medicine, McGill University, Montreal, QC H3A 0G4, Canada.;Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC H3A 0G4, Canada.;Five Prime Sciences Inc., Montreal, QC H3Y 2W4, Canada.;Department of Twin Research, King's College London, London SE1 7EH, UK. ^[7]

关键词 Mendelian randomization collider bias indirect genetic effects instrumental variable assumptions nonlinear analyses

医学主题词人类(Humans);孟德尔随机化分析(Mendelian Randomization Analysis);全基因组关联研究(Genome-Wide Association Study);研究设计(Research Design);因果律(Causality)

DOI 10.1210/clinem/dgaf305

PMID 40504703

发布时间 2025-08-29

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交