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Evolutionary-scale enzymology enables exploration of a rugged catalytic landscape.

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第一作者： Duncan F,Muir

第一单位： Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.;Program in Biophysics, University of California, San Francisco, San Francisco, CA, USA.

作者： Duncan F,Muir ^[1] ; Garrison P R,Asper ^[2] ; Pascal,Notin ^[3] ; Jacob A,Posner ^[4] ; Debora S,Marks ^[5] ; Michael J,Keiser ^[6] ; Margaux M,Pinney ^[7]

作者单位： Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.;Program in Biophysics, University of California, San Francisco, San Francisco, CA, USA. ^[1] Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA. ^[2] Department of Systems Biology, Harvard Medical School, Boston, MA, USA.;Department of Computer Science, University of Oxford, Oxford, UK. ^[3] Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.;Department of Biology, San Francisco State University, San Francisco, CA, USA. ^[4] Department of Systems Biology, Harvard Medical School, Boston, MA, USA.;Broad Institute of Harvard and MIT, Cambridge, MA, USA. ^[5] Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.;Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.;Bakar Computational Health Sciences Institute, University of California San Francisco, San Francisco, CA, USA. ^[6] Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.;Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA. ^[7]