首页> Frontiers in immunology> Chitinase-1 inhibition attenuates metabolic dysregulation and restores homeostasis in MASH animal models.

Chitinase-1 inhibition attenuates metabolic dysregulation and restores homeostasis in MASH animal models.

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第一作者： Katarzyna,Drzewicka

第一单位： Molecure S.A., Warsaw, Poland.

作者： Katarzyna,Drzewicka ^[1] ; Katarzyna M,Głuchowska ^[1] ; Michal,Mlącki ^[1] ; Bartłomiej,Hofman ^[1] ; Irina,Tuszyńska ^[1] ; Tristram A J,Ryan ^[2] ; Katarzyna,Piwowar ^[1] ; Bartosz,Wilczyński ^[3] ; Dorota,Dymkowska ^[4] ; Marcin M,Grzybowski ^[1] ; Barbara,Dymek ^[1] ; Tomasz,Rejczak ^[1] ; Kamil,Lisiecki ^[1] ; Adam,Gołębiowski ^[1] ; Adam,Jagielski ^[5] ; Angelika,Muchowicz ^[1] ; Dylan,Ryan ^[6] ; Krzysztof,Zabłocki ^[4] ; Luke A J,O'Neill ^[7] ; Zbigniew,Zasłona ^[1]

作者单位： Molecure S.A., Warsaw, Poland. ^[1] Division of Immunology, Division of Gastroenterology, Harvard Medical School and Boston Children's Hospital, Boston, MA, United States. ^[2] Institute of Informatics, Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Warsaw, Poland. ^[3] Laboratory of Cellular Metabolism, Nencki Institute of Experimental Biology, Warsaw, Poland. ^[4] Department of Metabolic Regulation, University of Warsaw, Warsaw, Poland. ^[5] The Medical Research Council (MRC) Mitochondrial Biology Unit, University of Cambridge, Cambridge, United Kingdom. ^[6] School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland. ^[7]

关键词 MASH OATD-01 chitinase 1 fibrosis glycolysis inflammation macrophage metabolism