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Naringenin and SMER28 target lysosomal reformation and rescue SPG11 and SPG15 hereditary spastic paraplegia phenotypes.

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第一作者： Chiara,Vantaggiato

第一单位： Scientific Institute IRCCS E. Medea, Laboratory of Medical Genetics, Via D. L. Monza 20, Bosisio Parini, Lecco 23842, Italy. Electronic address: chiara.vantaggiato@lanostrafamiglia.it.

作者： Chiara,Vantaggiato ^[1] ; Giulia,Guarato ^[2] ; Francesca,Brivio ^[3] ; Elena,Panzeri ^[4] ; Beatrice,Speltoni ^[2] ; Sentiljana,Gumeni ^[5] ; Genny,Orso ^[6] ; Filippo Maria,Santorelli ^[7] ; Maria Teresa,Bassi ^[4]

作者单位： Scientific Institute IRCCS E. Medea, Laboratory of Medical Genetics, Via D. L. Monza 20, Bosisio Parini, Lecco 23842, Italy. Electronic address: chiara.vantaggiato@lanostrafamiglia.it. ^[1] Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Largo E. Meneghetti 2, Padova, Italy. ^[2] Scientific Institute IRCCS E. Medea, Laboratory of Medical Genetics, Via D. L. Monza 20, Bosisio Parini, Lecco 23842, Italy; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Largo E. Meneghetti 2, Padova, Italy. ^[3] Scientific Institute IRCCS E. Medea, Laboratory of Medical Genetics, Via D. L. Monza 20, Bosisio Parini, Lecco 23842, Italy. ^[4] Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece. ^[5] Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Largo E. Meneghetti 2, Padova, Italy. Electronic address: genny.orso@unipd.it. ^[6] IRCCS Stella Maris Foundation, Pisa 56128, Italy. ^[7]

关键词 ALR Lysosomes Naringenin SMER28 SPG11 SPG15 Tideglusib