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Establishment of a humanized SCA2 mouse model carrying a CAA disruption preventing CAG repeat expansion in pathogenic genes.

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第一作者： Yao,Zhang

第一单位： School of Pharmaceutical Sciences, Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China.;Department of Medical Genetics, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China.;Department of Reproductive Genetics, Hebei General Hospital, Shijiazhuang, China.

作者： Yao,Zhang ^[1] ; Yufei,Li ^[2] ; Lin,Zhang ^[3] ; Zhaoqing,Li ^[4] ; Keqin,Lin ^[2] ; Kai,Huang ^[2] ; Zhaoqing,Yang ^[2] ; Shaohui,Ma ^[2] ; Hao,Sun ^[2] ; Xiaochao,Zhang ^[5]

作者单位： School of Pharmaceutical Sciences, Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China.;Department of Medical Genetics, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China.;Department of Reproductive Genetics, Hebei General Hospital, Shijiazhuang, China. ^[1] Department of Medical Genetics, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China. ^[2] Department of Pathology, People's Hospital of Qianxinan Prefecture, Xingyi, China. ^[3] Department of Medical Genetics, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China.;School of Life Sciences, Yunnan University, Kunming, China. ^[4] School of Pharmaceutical Sciences, Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, China.;Yunnan College of Modern Biomedical Industry, Kunming, China. ^[5]

关键词 ATXN2 CAA interruption SCA2 genetic stability mouse model