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Optimizing proton-pump inhibitor therapy in paediatric eosinophilic esophagitis through <i>CYP2C19</i> pharmacogenetic testing.

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第一作者： Sierra,Scodellaro

第一单位： Department of Paediatrics, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.

作者： Sierra,Scodellaro ^[1] ; Kristen A,Bortolin ^[2] ; Margaret A,Marcon ^[3] ; Ruud H J,Verstegen ^[4] ; Susana,Da Silva ^[5] ; Shinya,Ito ^[6] ; Tamorah,Lewis ^[6] ; Nicola L,Jones ^[3] ; Iris,Cohn ^[6] ; Jessie M,Hulst ^[7]

作者单位： Department of Paediatrics, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. ^[1] Department of Paediatrics, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. ^[2] Department of Paediatrics, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.;Department of Paediatrics, University of Toronto, Toronto, ON M5G 1X8, Canada. ^[3] Department of Paediatrics, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.;Department of Paediatrics, University of Toronto, Toronto, ON M5G 1X8, Canada.;Department of Paediatrics, Division of Rheumatology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. ^[4] Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada. ^[5] Department of Paediatrics, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.;Department of Paediatrics, University of Toronto, Toronto, ON M5G 1X8, Canada. ^[6] Department of Paediatrics, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.;Department of Paediatrics, University of Toronto, Toronto, ON M5G 1X8, Canada.;Department of Nutritional Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada. ^[7]

关键词 CYP2C19 eosinophilic esophagitis (EoE)pharmacogenetics (PGx)precision medicine second-generation proton-pump inhibitors (PPIs)

DOI 10.1093/jcag/gwaf003

PMID 40567296

发布时间 2025-06-26

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Journal of the Canadian Association of Gastroenterology

2025年8卷3期

89-96页

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Journal of the Canadian Association of Gastroenterology

2025年8卷3期

89-96页

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Optimizing proton-pump inhibitor therapy in paediatric eosinophilic esophagitis through <i>CYP2C19</i> pharmacogenetic testing.

Journal of the Canadian Association of Gastroenterology

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Optimizing proton-pump inhibitor therapy in paediatric eosinophilic esophagitis through <i>CYP2C19</i> pharmacogenetic testing.

Journal of the Canadian Association of Gastroenterology

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Journal of the Canadian Association of Gastroenterology

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