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Immunization with full-length TprC variants induces a broad response to surface-exposed epitopes of the Treponema pallidum repeat protein family and is partially protective in the rabbit model of syphilis.

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第一作者: Lorenzo,Giacani
第一单位: Department of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA; Department of Global Health, University of Washington, 3980 15th Ave NE, Seattle, WA 98105, USA. Electronic address: giacal@uw.edu.
作者单位: Department of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA; Department of Global Health, University of Washington, 3980 15th Ave NE, Seattle, WA 98105, USA. Electronic address: giacal@uw.edu. [1] Department of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: eromeis@uw.edu. [2] Department of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: amhaynes@uw.edu. [3] Department of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: bjmolini@uw.edu. [4] Department of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: ltantalo@uw.edu. [5] Department of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: lhx08@uw.edu. [6] Department of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA; Department of Global Health, University of Washington, 3980 15th Ave NE, Seattle, WA 98105, USA. Electronic address: atrejos2@uw.edu. [7] Department of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: jessica.keane@yale.edu. [8] Department of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: zmoham@uw.edu. [9] Department of Laboratory Medicine and Pathology, University of Washington, 825 Eastlake Ave E, Seattle, WA 98109, USA. Electronic address: tarmst@uw.edu. [10] Department of Laboratory Medicine and Pathology, University of Washington, 825 Eastlake Ave E, Seattle, WA 98109, USA. Electronic address: baw24@uw.edu. [11] Department of Laboratory Medicine and Pathology, University of Washington, 825 Eastlake Ave E, Seattle, WA 98109, USA. Electronic address: quynh.phung@wsu.edu. [12] Department of Laboratory Medicine and Pathology, University of Washington, 825 Eastlake Ave E, Seattle, WA 98109, USA. Electronic address: dvysh@uw.edu. [13] Department of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: vlc32@uw.edu. [14] Department of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: charmie@uw.edu. [15] Department of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA; Department of Global Health, University of Washington, 3980 15th Ave NE, Seattle, WA 98105, USA; Department of Laboratory Medicine and Pathology, University of Washington, 825 Eastlake Ave E, Seattle, WA 98109, USA; Benaroya Research Institute, 1201 9th Ave, Seattle, WA 98101, USA. Electronic address: dkoelle@medicine.washington.edu. [16] Department of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA. Electronic address: tbrinck@uw.edu. [17] VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: yang.wang2@vub.be. [18] VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: anastassia.andreevna.vorobieva@vub.be. [19] Department of Medicine, Division of Allergy & Infectious Diseases, University of Washington, 325 9th Ave, Seattle, WA 98104, USA; Department of Laboratory Medicine and Pathology, University of Washington, 825 Eastlake Ave E, Seattle, WA 98109, USA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109, USA; Department of Epidemiology, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA. Electronic address: annawald@uw.edu. [20] Department of Laboratory Medicine and Pathology, University of Washington, 825 Eastlake Ave E, Seattle, WA 98109, USA. Electronic address: naliebe@uw.edu. [21] Department of Laboratory Medicine and Pathology, University of Washington, 825 Eastlake Ave E, Seattle, WA 98109, USA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, Seattle, WA 98109, USA. Electronic address: agrening@uw.edu. [22]
DOI 10.1016/j.vaccine.2025.127406
PMID 40570746
发布时间 2025-09-25
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