首页> Biochemical pharmacology> Ghrelin attenuates metabolic dysfunction-associated steatotic liver disease by activating glutamine metabolism via inhibition of the IRE1α-XBP-1 pathway.

Ghrelin attenuates metabolic dysfunction-associated steatotic liver disease by activating glutamine metabolism via inhibition of the IRE1α-XBP-1 pathway.

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第一作者： Qian,Zhao

第一单位： Department of Gastroenterology, Wenzhou Medical University Affiliated Dongyang Hospital, Dongyang 322100 Zhejiang, China.

作者： Qian,Zhao ^[1] ; Jun,Xu ^[2] ; Ziqiang,Xia ^[2] ; Xiangyin,Lv ^[1] ; Yaling,Lou ^[3] ; Nan,Ye ^[4] ; Dandan,Zhu ^[2] ; Yixiao,Wang ^[2] ; Yuan,Zeng ^[2] ; Xiangting,Zhang ^[2] ; Weimin,Cai ^[2] ; Huiya,Ying ^[2] ; Ruoru,Zhou ^[2] ; Tianhao,Weng ^[5] ; Fujun,Yu ^[6]

作者单位： Department of Gastroenterology, Wenzhou Medical University Affiliated Dongyang Hospital, Dongyang 322100 Zhejiang, China. ^[1] Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000 Zhejiang, China. ^[2] Department of Infectious Diseases, Wenzhou Medical University Affiliated Dongyang Hospital, 322100 Zhejiang, China. ^[3] Department of Hepatobiliary Surgery, Wenzhou Medical University Affiliated Dongyang Hospital, Dongyang 322100 Zhejiang, China. ^[4] Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000 Zhejiang, China. Electronic address: wengtianhao@wzhospital.cn. ^[5] Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000 Zhejiang, China. Electronic address: yufujun@wmu.edu.cn. ^[6]

关键词 ASCT2/mTORC1/SCD1 signaling Endoplasmic reticulum stress Ferroptosis Ghrelin Metabolic dysfunction-associated steatotic liver disease