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Development and External Validation of a Genetic Risk Score for Pain in Rheumatoid Arthritis.

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第一作者： Katie J,McMenamin

第一单位： Boston Medical Center, Boston, Massachusetts.

作者： Katie J,McMenamin ^[1] ; Thomas R,Riley ^[2] ; Kristin,Wipfler ^[3] ; Kaleb,Michaud ^[4] ; Austin,Wheeler ^[5] ; Bryant R,England ^[5] ; Brian,Sauer ^[6] ; Katherine D,Wysham ^[7] ; Rui,Xiao ^[8] ; Michael,March ^[9] ; Grant W,Cannon ^[6] ; Sylvanus,Toikumo ^[2] ; Henry R,Kranzler ^[2] ; Rachel L,Kember ^[2] ; Ted R,Mikuls ^[5] ; Joshua F,Baker ^[2]

作者单位： Boston Medical Center, Boston, Massachusetts. ^[1] University of Pennsylvania and Corporal Michael J. Crescenz Department of Veterans Affairs Medical Center, Philadelphia. ^[2] FORWARD, The National Databank for Rheumatic Diseases, Wichita, Kansas. ^[3] FORWARD, The National Databank for Rheumatic Diseases, Wichita, Kansas, and VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha. ^[4] VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha. ^[5] Salt Lake City VA Medical Center and University of Utah, Salt Lake City. ^[6] VA Puget Sound Health Care System and University of Washington, Seattle. ^[7] University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia. ^[8] Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. ^[9]

医学主题词人类(Humans);关节炎, 类风湿(Arthritis, Rheumatoid);女(雌)性(Female);男(雄)性(Male);中年人(Middle Aged);多态性, 单核苷酸(Polymorphism, Single Nucleotide);疾病遗传易感性(Genetic Predisposition to Disease);老年人(Aged);疼痛测定(Pain Measurement);危险因素(Risk Factors);横断面研究(Cross-Sectional Studies);危险性评估(Risk Assessment);登记(Registries);纤维肌痛(Fibromyalgia);结果可重复性(Reproducibility of Results);疾病严重程度指数(Severity of Illness Index)

DOI 10.1002/acr.25588

PMID 40583606

发布时间 2026-03-07

基金项目

IK2 CX002203/CX/CSRD VA/United States PR200793/U.S. Department of Defense 5T32GM075766-17/NH/NIH HHS/United States I01 RX003644/RX/RRD VA/United States ::Horizon Therapeutics:: U54GM115458/GM/NIGMS NIH HHS/United States CX002351/Clinical Science Research and Development I01 CX001703/CX/CSRD VA/United States

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