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The hierarchical folding dynamics of topologically associating domains during early embryo development.

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第一作者： Xuemei,Bai

第一单位： Department of Obstetrics and Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.;Academy of Military Medical Science, Beijing, 100850, China.

作者： Xuemei,Bai ^[1] ; Xiaohan,Tang ^[2] ; Yuyang,Wang ^[3] ; Shutong,Yue ^[4] ; Xiang,Xu ^[5] ; Pengzhen,Hu ^[6] ; Jingxuan,Xu ^[5] ; Yaru,Li ^[5] ; Junting,Wang ^[1] ; Huan,Tao ^[5] ; Yang,Zheng ^[5] ; Bijia,Chen ^[5] ; Mengge,Tian ^[1] ; Lin,Lin ^[5] ; Ruiqing,Wang ^[5] ; Yu,Sun ^[5] ; Chao,Ren ^[5] ; Xiaochen,Bo ^[5] ; Hao,Li ^[7] ; Hebing,Chen ^[8] ; Meisong,Lu ^[9]

作者单位： Department of Obstetrics and Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.;Academy of Military Medical Science, Beijing, 100850, China. ^[1] Department of Obstetrics and Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China. ^[2] Academy of Military Medical Science, Beijing, 100850, China.;College of Computer and Data Science, Fuzhou University, Fuzhou, 350108, China. ^[3] Academy of Military Medical Science, Beijing, 100850, China.;Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. ^[4] Academy of Military Medical Science, Beijing, 100850, China. ^[5] Academy of Military Medical Science, Beijing, 100850, China.;School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710000, China. ^[6] Academy of Military Medical Science, Beijing, 100850, China. lihao_thu@163.com. ^[7] Academy of Military Medical Science, Beijing, 100850, China. chenhb@bmi.ac.cn. ^[8] Department of Obstetrics and Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China. lumeisong0417@163.com. ^[9]

关键词 Deep neural network Early embryo Hi-C Hierarchical TAD

医学主题词胚胎发育(Embryonic Development);动物(Animals);染色质(Chromatin);基因表达调控, 发育期(Gene Expression Regulation, Developmental);组蛋白类(Histones);合子(Zygote);小鼠(Mice)

DOI 10.1186/s12915-025-02259-y

PMID 40597210

发布时间 2026-09-25

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