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Deficient AMPK-SENP1-Sirt3 signaling impairs mitochondrial complex I function in Parkinson's disease model.

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第一作者： Xiaoyu,Sun

第一单位： Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Second Road, Shanghai, 200025, China.;Department of Neurology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

作者： Xiaoyu,Sun ^[1] ; Jianyi,Shen ^[2] ; Yimei,Shu ^[3] ; Tianshi,Wang ^[4] ; Lu,He ^[3] ; Ruinan,Shen ^[3] ; Yifan,Zhou ^[3] ; Jinke,Cheng ^[5] ; Suzhen,Lin ^[6] ; Jianqing,Ding ^[7]

作者单位： Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Second Road, Shanghai, 200025, China.;Department of Neurology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[1] Institute of Aging and Tissue Regeneration, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 160 Pujian Road, Shanghai, 200135, China. ^[2] Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Second Road, Shanghai, 200025, China. ^[3] Department of Nephrology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[4] Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[5] Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Second Road, Shanghai, 200025, China. lsz01c37@rjh.com.cn. ^[6] Institute of Aging and Tissue Regeneration, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 160 Pujian Road, Shanghai, 200135, China. jqding18@shsmu.edu.cn. ^[7]

关键词 MPTP Mitochondrial complex I Parkinson's disease SENP1 Sirt3