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The CALHM1 blocker CGP37157 increases seizure severity during status epilepticus in adult mice.

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第一作者： Meghma,Mitra

第一单位： Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin, D02 YN77, Ireland.;FutureNeuro Research Ireland Centre, RCSI University of Medicine and Health Sciences, Dublin, D02 YN77, Ireland.

作者： Meghma,Mitra ^[1] ; Amaya Sanz,Rodriguez ^[1] ; Norman,Delanty ^[2] ; Alan,Beausang ^[3] ; Francesca M,Brett ^[3] ; Michael A,Farrell ^[3] ; Jane,Cryan ^[3] ; Donncha F,O'Brien ^[4] ; David,Henshall ^[1] ; Maria F,Cano-Abad ^[5] ; Tobias,Engel ^[6]

作者单位： Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin, D02 YN77, Ireland.;FutureNeuro Research Ireland Centre, RCSI University of Medicine and Health Sciences, Dublin, D02 YN77, Ireland. ^[1] FutureNeuro Research Ireland Centre, RCSI University of Medicine and Health Sciences, Dublin, D02 YN77, Ireland.;Department of Neurology, Beaumont Hospital, Dublin, Ireland. ^[2] Department of Neuropathology, Beaumont Hospital, Dublin, Ireland. ^[3] Department of Neurosurgery, Beaumont Hospital, Dublin, Ireland. ^[4] Departamento de Farmacología, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain. maria.cano@uam.es.;Instituto de Investigación Sanitaria, Hospital Universitario de La Princesa, Universidad Autónoma de Madrid, Madrid, Spain. maria.cano@uam.es. ^[5] Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin, D02 YN77, Ireland. tengel@rcsi.ie.;FutureNeuro Research Ireland Centre, RCSI University of Medicine and Health Sciences, Dublin, D02 YN77, Ireland. tengel@rcsi.ie. ^[6]

关键词 CALHM1 Epilepsy Intra-amygdala kainate model Resected tissue from TLE patients Status epilepticus