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Esketamine Monotherapy in Adults With Treatment-Resistant Depression: A Randomized Clinical Trial.

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第一作者： Adam,Janik

第一单位： Department of Neuroscience, Johnson & Johnson, San Diego, California.

作者： Adam,Janik ^[1] ; Xin,Qiu ^[2] ; Rosanne,Lane ^[2] ; Vanina,Popova ^[3] ; Wayne C,Drevets ^[1] ; Carla M,Canuso ^[4] ; Matthew,Macaluso ^[5] ; Gregory W,Mattingly ^[6] ; Richard C,Shelton ^[7] ; John M,Zajecka ^[8] ; Dong-Jing,Fu ^[4]

作者单位： Department of Neuroscience, Johnson & Johnson, San Diego, California. ^[1] Department of Clinical Biostatistics, Johnson & Johnson, Titusville, New Jersey. ^[2] Department of Neuroscience, Johnson & Johnson, Beerse, Belgium. ^[3] Department of Neuroscience, Johnson & Johnson, Titusville, New Jersey. ^[4] Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham. ^[5] Midwest Research Group-St Charles Psychiatric Associates, St Charles, Missouri. ^[6] Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham School of Medicine, Huntsville Regional Medical Campus, Huntsville. ^[7] Department of Psychiatry, Rush University, Chicago, Illinois. ^[8]

医学主题词人类(Humans);氯胺酮(Ketamine);男(雄)性(Male);女(雌)性(Female);双盲法(Double-Blind Method);中年人(Middle Aged);成年人(Adult);投药, 鼻内(Administration, Intranasal);抗抑郁药(Antidepressive Agents);抑郁症, 更年期(Depressive Disorder, Major);治疗结果(Treatment Outcome)

DOI 10.1001/jamapsychiatry.2025.1317

PMID 40601310

发布时间 2025-09-03

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2025年82卷9期

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Esketamine Monotherapy in Adults With Treatment-Resistant Depression: A Randomized Clinical Trial.

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JAMA psychiatry

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