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Synovial tissue atlas in juvenile idiopathic arthritis reveals pathogenic niches associated with disease severity.

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第一作者: Chrissy,Bolton
第一单位: Infection, Immunity, and Inflammation Research and Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.;Department of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK.;Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.
作者单位: Infection, Immunity, and Inflammation Research and Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.;Department of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK.;Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK. [1] Department of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK. [2] Department of Biomedicine, Aarhus University, Aarhus, Denmark, DK-8000.;Department of Pediatric and Adolescent Medicine, Aarhus University Hospital, Aarhus DK-8200, Denmark. [3] Department of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK.;Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), University of Birmingham, Birmingham B15 2TT, UK. [4] Department of Ageing, Rheumatology and Regenerative Medicine, Division of Medicine, UCL, London WC1E 6JF, UK.;Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCL Hospitals and Great Ormond Street Hospital, London WC1E 6JF, UK. [5] Infection, Immunity, and Inflammation Research and Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.;NIHR Biomedical Research Centre at Great Ormond Street Hospital NHS Foundation Trust, London WC1N 3JH, UK. [6] Birmingham Women's and Children's Hospital NHS Foundation Trust, Birmingham B15 2TG, UK. [7] NIHR Biomedical Research Centre at Great Ormond Street Hospital NHS Foundation Trust, London WC1N 3JH, UK.;Department of Interventional Radiology, Great Ormond Street Hospital NHS Foundation Trust, London WC1N 3JH, UK. [8] NIHR Biomedical Research Centre at Great Ormond Street Hospital NHS Foundation Trust, London WC1N 3JH, UK.;Department of Rheumatology, Great Ormond Street Hospital NHS Foundation Trust, London WC1N 3JH, UK. [9] Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. [10] Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY 10021, USA. [11] Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK.;National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WU, UK. [12] Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.;Broad Institute of Massachusetts Institute of Technology, Cambridge, MA 02142, USA. [13] Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.;Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.;Broad Institute of Massachusetts Institute of Technology, Cambridge, MA 02142, USA. [14] Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK. [15] Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.;National Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre, Oxford OX3 9DU, UK.;Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), University of Oxford, Oxford OX3 7FY, UK. [16] Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.;Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), University of Oxford, Oxford OX3 7FY, UK. [17] Department of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK.;Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), University of Birmingham, Birmingham B15 2TT, UK.;National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham B15 2TH, UK. [18] Infection, Immunity, and Inflammation Research and Teaching Department, University College London (UCL) Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.;Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCL Hospitals and Great Ormond Street Hospital, London WC1E 6JF, UK.;NIHR Biomedical Research Centre at Great Ormond Street Hospital NHS Foundation Trust, London WC1N 3JH, UK. [19]
DOI 10.1126/scitranslmed.adt6050
PMID 40601776
发布时间 2025-09-09
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