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Mapping and engineering RNA-driven architecture of the multiphase nucleolus.

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第一作者： Sofia A,Quinodoz

第一单位： Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA.;Howard Hughes Medical Institute, Chevy Chase, MD, USA.

作者： Sofia A,Quinodoz ^[1] ; Lifei,Jiang ^[2] ; Aya A,Abu-Alfa ^[2] ; Troy J,Comi ^[3] ; Hongbo,Zhao ^[4] ; Qiwei,Yu ^[5] ; Lennard W,Wiesner ^[6] ; Jordy F,Botello ^[2] ; Anita,Donlic ^[6] ; Elizabeth,Soehalim ^[3] ; Prashant,Bhat ^[7] ; Christiane,Zorbas ^[8] ; Ludivine,Wacheul ^[8] ; Andrej,Košmrlj ^[9] ; Denis L J,Lafontaine ^[10] ; Sebastian,Klinge ^[11] ; Clifford P,Brangwynne ^[12]

作者单位： Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA.;Howard Hughes Medical Institute, Chevy Chase, MD, USA. ^[1] Department of Molecular Biology, Princeton University, Princeton, NJ, USA. ^[2] Omenn-Darling Bioengineering Institute, Princeton University, Princeton, NJ, USA. ^[3] Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA.;Omenn-Darling Bioengineering Institute, Princeton University, Princeton, NJ, USA. ^[4] Lewis-Sigler Institute for Integrative Genomics, Princeton, NJ, USA. ^[5] Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA. ^[6] Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.;David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. ^[7] RNA Molecular Biology, Fonds de la Recherche Scientifique (F.R.S./FNRS), Université libre de Bruxelles (ULB), Gosselies, Belgium. ^[8] Department of Mechanical and Aerospace Engineering, Princeton, NJ, USA.;Princeton Materials Institute, Princeton, NJ, USA. ^[9] RNA Molecular Biology, Fonds de la Recherche Scientifique (F.R.S./FNRS), Université libre de Bruxelles (ULB), Gosselies, Belgium. denis.lafontaine@ulb.be. ^[10] Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, NY, USA. klinge@rockefeller.edu. ^[11] Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA. cbrangwy@princeton.edu.;Howard Hughes Medical Institute, Chevy Chase, MD, USA. cbrangwy@princeton.edu.;Department of Molecular Biology, Princeton University, Princeton, NJ, USA. cbrangwy@princeton.edu.;Omenn-Darling Bioengineering Institute, Princeton University, Princeton, NJ, USA. cbrangwy@princeton.edu.;Lewis-Sigler Institute for Integrative Genomics, Princeton, NJ, USA. cbrangwy@princeton.edu.;Princeton Materials Institute, Princeton, NJ, USA. cbrangwy@princeton.edu. ^[12]

医学主题词细胞核仁(Cell Nucleolus);RNA, 核糖体(RNA, Ribosomal);RNA加工, 转录后(RNA Processing, Post-Transcriptional);人类(Humans);DNA, 核糖体(DNA, Ribosomal)

DOI 10.1038/s41586-025-09207-4

PMID 40604277

发布时间 2026-04-15

基金项目

F30 CA247447/CA/NCI NIH HHS/United States T32 GM007616/GM/NIGMS NIH HHS/United States T32 GM152342/GM/NIGMS NIH HHS/United States T32 GM008042/GM/NIGMS NIH HHS/United States R01 GM143181/GM/NIGMS NIH HHS/United States R01 GM145950/GM/NIGMS NIH HHS/United States

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