首页> International journal of biological sciences> Interferon Regulatory Factor 4 Recruits Immature B Cells to Signal Tertiary Lymphoid Structure Immaturity and Progression of Clear Cell Renal Cell Carcinoma.

Interferon Regulatory Factor 4 Recruits Immature B Cells to Signal Tertiary Lymphoid Structure Immaturity and Progression of Clear Cell Renal Cell Carcinoma.

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第一作者： Siqi,Zhou

第一单位： Department of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.;Shanghai Genitourinary Cancer Institute, Shanghai, 200032, China.

作者： Siqi,Zhou ^[1] ; Shiqi,Ye ^[2] ; Liang,Chen ^[3] ; Qintao,Ge ^[1] ; Jiahe,Lu ^[1] ; Aihetaimujiang,Anwaier ^[1] ; Xi,Tian ^[1] ; Zhongyuan,Wang ^[1] ; Shuxuan,Zhu ^[1] ; Kun,Chang ^[1] ; Jianfeng,Yang ^[4] ; Tian,Li ^[5] ; Hailiang,Zhang ^[1] ; Dingwei,Ye ^[1] ; Jianfeng,Xiang ^[6] ; Wenhao,Xu ^[1]

作者单位： Department of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.;Shanghai Genitourinary Cancer Institute, Shanghai, 200032, China. ^[1] Department of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.;Shanghai Genitourinary Cancer Institute, Shanghai, 200032, China.;Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. ^[2] Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus (Shanghai Fengxian District Central Hospital), Shanghai, 201400, China. ^[3] Department of Urology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China. ^[4] Tianjin Key Laboratory of Acute Abdomen Disease-Associated Organ Injury and ITCWM Repair, Institute of Integrative Medicine of Acute Abdominal Diseases, Tianjin Nankai Hospital, Tianjin Medical University, 8 Changjiang Avenue, Tianjin, 300100, China. ^[5] Department of Interventional Oncology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, P.R. China. ^[6]

关键词 clear cell renal cell carcinoma (ccRCC)interferon regulatory factor 4 (IRF4)single-cell RNA sequencing (scRNA-seq)spatial transcriptomics analysis tertiary lymphoid structures (TLSs)tumor microenvironment (TME)