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Optimizing dose selection for doxorubicin-induced cardiotoxicity in mice: A comprehensive analysis of single and multiple-dose regimens.

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第一作者： Min,Li

第一单位： Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, China.

作者： Min,Li ^[1] ; Yiyin,Zhang ^[1] ; Bohan,Wu ^[1] ; Ruijing,Qiu ^[2] ; Chen,Zhao ^[3] ; Buxing,Chen ^[4] ; Hongcai,Shang ^[5]

作者单位： Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, China. ^[1] Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. ^[2] Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China. ^[3] Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, China. Electronic address: chbux@126.com. ^[4] Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China. Electronic address: shanghongcai@126.com. ^[5]

关键词 Acute cardiotoxicity Chronic cardiotoxicity Dose selection Doxorubicin Mouse models

医学主题词动物(Animals);多柔比星(Doxorubicin);小鼠(Mice);剂量效应关系, 药物(Dose-Response Relationship, Drug);抗生素类, 抗肿瘤(Antibiotics, Antineoplastic)

DOI 10.1016/j.ejphar.2025.177883

PMID 40615106

发布时间 2025-08-05

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