首页> International journal of biological macromolecules> Targeting tau hyperphosphorylation-mediated neuroinflammation in Alzheimer's disease via ABL1 kinase inhibition: Insights from microsecond MD simulation and MM/PBSA analyses.

Targeting tau hyperphosphorylation-mediated neuroinflammation in Alzheimer's disease via ABL1 kinase inhibition: Insights from microsecond MD simulation and MM/PBSA analyses.

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第一作者： Arunabh,Choudhury

第一单位： Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.

作者： Arunabh,Choudhury ^[1] ; Sneh,Prabha ^[1] ; Mohammad Umar,Saeed ^[1] ; Taj,Mohammad ^[1] ; Afzal,Hussain ^[2] ; Mohamed F,AlAjmi ^[2] ; Faez Iqbal,Khan ^[3] ; Asimul,Islam ^[1] ; Md Imtaiyaz,Hassan ^[4]

作者单位： Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. ^[1] Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. ^[2] Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou, China. ^[3] Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. Electronic address: mihassan@jmi.ac.in. ^[4]

关键词 Alzheimer's disease Drug discovery MM/PBSA Molecular dynamics simulation Tauopathies