换一批Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes.
第一作者：
Cristina T,Vicente
第一单位：
Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.;VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
作者：
Cristina T,Vicente [1]
;
Tejasvi,Niranjan [1]
;
Elise,Coopman [1]
;
Júlia,Faura [1]
;
Sara,Alidadiani [1]
;
Claudia,Schrauwen [1]
;
Billie J,Matchett [2]
;
Bavo,Heeman [1]
;
Marleen,Van den Broeck [1]
;
Wouter,De Coster [1]
;
Thuy,Nguyen [3]
;
Julie S,Lau [4]
;
Saurabh,Baheti [5]
;
Tim,de Pooter [6]
;
Peter,De Rijk [6]
;
Mojca,Strazisar [6]
;
Matt,Baker [3]
;
Mariely,DeJesus-Hernandez [3]
;
NiCole A,Finch [7]
;
Cyril,Pottier [8]
;
Marka,van Blitterswijk [3]
;
Yan,Asmann [9]
;
Melissa E,Murray [3]
;
Leonard,Petrucelli [3]
;
Andrew,King [10]
;
Claire,Troakes [11]
;
Safa,Al-Sarraj [12]
;
Robert A,Rissman [13]
;
Annie,Hiniker [14]
;
Margaret,Flanagan [15]
;
Bret M,Evers [16]
;
Charles L,White [16]
;
Carlos,Cruchaga [17]
;
Rudolph,Castellani [18]
;
Jeroen G J,van Rooij [19]
;
Merel O,Mol [20]
;
Harro,Seelaar [19]
;
John C,van Swieten [19]
;
Björn,Oskarsson [21]
;
Robert Ross,Reichard [22]
;
Aivi T,Nguyen [22]
;
Keith A,Josephs [23]
;
Ronald C,Petersen [23]
;
Nilüfer,Ertekin-Taner [24]
;
Bradley F,Boeve [23]
;
Neill R,Graff-Radford [21]
;
Sarah,Weckhuysen [25]
;
Dennis W,Dickson [3]
;
Rosa,Rademakers [26]
作者单位：
Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.;VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
[1]
Division of Neuroscience, University of Manchester, Manchester, UK.;Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
[2]
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
[3]
Genome Analysis Core, Mayo Clinic, Rochester, MN, USA.
[4]
Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
[5]
Neuromics Support Facility, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.;Neuromics Support Facility, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
[6]
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.;Department of Neurology, Vanderbilt University Medical Center, Neuromuscular Division, Nashville, TN, USA.
[7]
Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.;VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.;Department of Neurology, Washington University School of Medicine, St Louis, MO, USA.;NeuroGenomics and Informatics Center, Washington University School of Medicine, St Louis, MO, USA.
[8]
Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA.
[9]
Department of Basic and Clinical Neuroscience, London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.;Department of Clinical Neuropathology, King's College Hospital NHS Foundation Trust, London, UK.
[10]
Department of Basic and Clinical Neuroscience, London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
[11]
Department of Basic and Clinical Neuroscience, London Neurodegenerative Diseases Brain Bank, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.;King's College Hospital NHS Foundation Trust, London, UK.
[12]
Department of Neurosciences, University of California San Diego, San Diego, CA, USA.;Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
[13]
Department of Pathology, University of Southern California, Los Angeles, CA, USA.
[14]
University of Texas Health Science Center San Antonio, San Antonio, TX, USA.
[15]
Division of Neuropathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
[16]
Department of Psychiatry, Knight Alzheimer Disease Research Center, Washington University School of Medicine, Saint Louis, MO, USA.
[17]
Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
[18]
Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.
[19]
Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands.
[20]
Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
[21]
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
[22]
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
[23]
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.;Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
[24]
VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.;Department of Neurology, Antwerp University Hospital, Antwerp, Belgium.;Translational Neurosciences, Faculty of Medicine and Health Science, University of Antwerp, Antwerp, Belgium.
[25]
Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium. rosa.rademakers@uantwerpen.vib.be.;VIB Center for Molecular Neurology, VIB, Antwerp, Belgium. rosa.rademakers@uantwerpen.vib.be.;Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. rosa.rademakers@uantwerpen.vib.be.
[26]
医学主题词
人类(Humans);额颞叶变性(Frontotemporal Lobar Degeneration);DNA甲基化(DNA Methylation);男(雄)性(Male);女(雌)性(Female);老年人(Aged);DNA结合蛋白质类(DNA-Binding Proteins);后成说, 遗传(Epigenesis, Genetic);中年人(Middle Aged);老年人, 80以上(Aged, 80 and over);病例对照研究(Case-Control Studies)
DOI
10.1186/s13024-025-00869-2
PMID
40619440
发布时间
2026-05-16
- 浏览0
Molecular neurodegeneration
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