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The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1<sup>+</sup>CD8<sup>+</sup> T cells.

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第一作者: Etienne,Humblin
第一单位: Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Immunology and Immunotherapy, ISMMS, New York, NY 10029, USA. Electronic address: etienne.humblin@gmail.com.
作者单位: Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Immunology and Immunotherapy, ISMMS, New York, NY 10029, USA. Electronic address: etienne.humblin@gmail.com. [1] Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Immunology and Immunotherapy, ISMMS, New York, NY 10029, USA. [2] Tisch Cancer Institute, ISMMS, New York, NY 10029, USA; Department of Oncological Sciences, ISMMS, New York, NY 10029, USA. [3] Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. [4] Federal University of Alagoas, Arapiraca Campus, Center of Medical Sciences, Bom Sucesso, Alagoas 57309, Brazil. [5] Department of Microbiology, ISMMS, New York, NY 10029, USA. [6] Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Icahn Genomics Institute, ISMMS, New York, NY 10029, USA. [7] Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508, Brazil; Hospital Israelita Albert Einstein, São Paulo 05620, Brazil. [8] Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Immunology and Immunotherapy, ISMMS, New York, NY 10029, USA; Tisch Cancer Institute, ISMMS, New York, NY 10029, USA; Icahn Genomics Institute, ISMMS, New York, NY 10029, USA. [9] Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Tisch Cancer Institute, ISMMS, New York, NY 10029, USA; Department of Oncological Sciences, ISMMS, New York, NY 10029, USA. [10] Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Tisch Cancer Institute, ISMMS, New York, NY 10029, USA; Department of Oncological Sciences, ISMMS, New York, NY 10029, USA; Department of Pathology, ISMMS, New York, NY 10029, USA. [11] Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Immunology and Immunotherapy, ISMMS, New York, NY 10029, USA; Tisch Cancer Institute, ISMMS, New York, NY 10029, USA; Department of Oncological Sciences, ISMMS, New York, NY 10029, USA. Electronic address: alice.kamphorst@mssm.edu. [12]
DOI 10.1016/j.immuni.2025.06.001
PMID 40628269
发布时间 2025-10-01
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Immunity

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