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Ethanol consumption aggravates amyloid pathology and neuroinflammation in Alzheimer's disease associated with inflammasome activation and ASC speck propagation.

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第一作者： Veronika,Brezani

第一单位： Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

作者： Veronika,Brezani ^[1] ; Radhika S,Joshi ^[1] ; Marti,Ortega-Ribera ^[1] ; Prashanth Thevkar,Nagesh ^[1] ; Viliam,Brezani ^[1] ; Adam,Zivny ^[1] ; Evelyn A,Kurt-Jones ^[2] ; Douglas T,Golenbock ^[2] ; Gyongyi,Szabo ^[3]

作者单位： Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. ^[1] Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA. ^[2] Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. gszabo1@bidmc.harvard.edu.;Broad Institute of MIT and Harvard, Cambridge, MA, USA. gszabo1@bidmc.harvard.edu. ^[3]

关键词 ASC specks Alcohol use disorder Alzheimer’s Astrocytes Ethanol Inflammasome Microglia Neuroinflammation

医学主题词动物(Animals);阿尔茨海默病(Alzheimer Disease);小鼠(Mice);炎性体(Inflammasomes);乙醇(Ethanol);小鼠, 转基因(Mice, Transgenic);CARD信号接头蛋白质类(CARD Signaling Adaptor Proteins);小鼠, 近交C57BL(Mice, Inbred C57BL);男(雄)性(Male);饮酒(Alcohol Drinking);中枢神经系统抑制药(Central Nervous System Depressants);淀粉样β肽类(Amyloid beta-Peptides)

DOI 10.1186/s12974-025-03501-8

PMID 40665351

发布时间 2025-07-19

基金项目

R01 AA017729/AA/NIAAA NIH HHS/United States R01 AG072899/AG/NIA NIH HHS/United States 5R01AG072899/GF/NIH HHS/United States 5R01AA017729/AA/NIAAA NIH HHS/United States

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