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Structural variability of apolipoprotein A-I amyloid fibrils across organs, mutations, and clinical presentations, revealed by cryo-EM.

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第一作者： Binh,An Nguyen

第一单位： Center for Alzheimer's and Neurodegenerative Diseases, Department of Biophysics, Peter O'Donnell Jr Brain Institute, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA.

作者： Binh,An Nguyen ^[1] ; Maria,Del Carmen Fernandez-Ramirez ^[1] ; Parker,Bassett ^[1] ; Virender,Singh ^[2] ; Preeti,Singh ^[1] ; Maja,Pękała ^[1] ; Layla,Villalon ^[1] ; Yasmin,Ahmed ^[1] ; Andrew,Lemoff ^[3] ; Bret,Evers ^[4] ; Christian,Lopez ^[5] ; Barbara,Kluve-Beckerman ^[6] ; Lorena,Saelices ^[1]

作者单位： Center for Alzheimer's and Neurodegenerative Diseases, Department of Biophysics, Peter O'Donnell Jr Brain Institute, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA. ^[1] SciKonnect and BioPatriKa, India. ^[2] Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA. ^[3] Department of Pathology, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA.;Department of Ophthalmology, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA. ^[4] Department of Internal Medicine, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA. ^[5] Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. ^[6]

DOI 10.1101/2025.07.08.663734

PMID 40672337

发布时间 2026-06-16

基金项目

DP2 HL163810/HL/NHLBI NIH HHS/United States R01 GM129325/GM/NIGMS NIH HHS/United States R24 GM154186/GM/NIGMS NIH HHS/United States

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Structural variability of apolipoprotein A-I amyloid fibrils across organs, mutations, and clinical presentations, revealed by cryo-EM.

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Structural variability of apolipoprotein A-I amyloid fibrils across organs, mutations, and clinical presentations, revealed by cryo-EM.

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