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Interferon gamma rebalances immunopathological signatures in Chronic Granulomatous Disease through metabolic rewiring.

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第一作者: Mariolina,Bruno
第一单位: Department of Internal Medicine and Radboudumc Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, Netherlands.
作者单位: Department of Internal Medicine and Radboudumc Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, Netherlands. [1] DZNE, Bonn, Germany. [2] Radboud University Nijmegen Medical Centre, Cambridge, Massachusetts, United States. [3] Department of Computational Biology for Individualised Medicine, Centre for Individualised Infection Medicine (CiiM), a joint venture between the Hannover Medical School (MHH) and the Helmholtz Cent, Hannover, Germany. [4] Murdoch Children's Research Institute, Parkville, Australia. [5] Radboud University Medical Center, Nijmegen, Netherlands. [6] Microbial Evolution Research Manchester, Division of Evolution, Infection and Genomic Sciences, Faculty of Medicine, Biology and Health, University of Manchester,, Manchester, United Kingdom. [7] Centre for Metabolomics and Bioanalysis (CEMBIO), Chemistry and Biochemistry Department, Pharmacy Faculty, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain. [8] Life and Medical Sciences Institute, University of Bonn, Bonn, Germany. [9] Department of Medical Genetics, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. [10] Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Bonn, Germany. [11] PRECISE Platform for Single Cell Genomics and Epigenomics, DZNE and University of Bonn, Bonn, Germany. [12] Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany. [13] German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. [14] Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany. [15] Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Bonn, Germany. [16] Deutsches Zentrum für Neurodegenerative Erkrankungen, DZNE, Bonn, Germany. [17] Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany. [18] Universitätsklinikum Schleswig-Holstein (UKSH), University of Lübeck and University of Kiel, Lübeck, Germany. [19] University of Minho, Braga, Portugal. [20] HOT Screen GmbH, Reutlingen, Germany. [21] Radboud university medical center, Nijmegen, Netherlands. [22] Universidad CEU San Pablo CEMBIO, Madrid, Spain. [23] Department of Computational Biology for Individualised Medicine, Centre for Individualised Infection Medicine (CiiM), Hannover, Germany. [24]
DOI 10.1182/bloodadvances.2025016213
PMID 40674716
发布时间 2025-07-17
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