换一批Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease.
第一作者：
Farid,Rajabli
第一单位：
Dr. John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA.;The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
作者：
Farid,Rajabli [1]
;
Penelope,Benchek [2]
;
Giuseppe,Tosto [3]
;
Nicholas,Kushch [4]
;
Jin,Sha [5]
;
Katrina,Bazemore [5]
;
Congcong,Zhu [6]
;
Wan-Ping,Lee [7]
;
Jacob,Haut [5]
;
Kara L,Hamilton-Nelson [4]
;
Nicholas R,Wheeler [8]
;
Yi,Zhao [7]
;
John J,Farrell [6]
;
Michelle A,Grunin [2]
;
Yuk Yee,Leung [7]
;
Pavel P,Kuksa [7]
;
Donghe,Li [6]
;
Eder Lucio,da Fonseca [4]
;
Jesse B,Mez [9]
;
Ellen L,Palmer [2]
;
Jagan,Pillai [10]
;
Richard M,Sherva [6]
;
Yeunjoo E,Song [8]
;
Xiaoling,Zhang [11]
;
Takeshi,Ikeuchi [12]
;
Taha,Iqbal [5]
;
Omkar,Pathak [7]
;
Otto,Valladares [7]
;
Dolly,Reyes-Dumeyer [3]
;
Amanda B,Kuzma [7]
;
Erin,Abner [13]
;
Larry D,Adams [14]
;
Perrie M,Adams [15]
;
Alyssa,Aguirre [16]
;
Marilyn S,Albert [17]
;
Roger L,Albin [18]
;
Mariet,Allen [19]
;
Lisa,Alvarez [20]
;
Liana G,Apostolova [21]
;
Steven E,Arnold [22]
;
Sanjay,Asthana [23]
;
Craig S,Atwood [23]
;
Sanford,Auerbach [9]
;
Gayle,Ayres [16]
;
Clinton T,Baldwin [6]
;
Robert C,Barber [20]
;
Lisa L,Barnes [24]
;
Sandra,Barral [25]
;
Thomas G,Beach [26]
;
James T,Becker [27]
;
Gary W,Beecham [4]
;
Duane,Beekly [28]
;
Bruno A,Benitez [29]
;
David,Bennett [30]
;
John,Bertelson [31]
;
Thomas D,Bird [32]
;
Deborah,Blacker [33]
;
Bradley F,Boeve [34]
;
James D,Bowen [35]
;
Adam,Boxer [36]
;
James,Brewer [37]
;
James R,Burke [38]
;
Jeffrey M,Burns [39]
;
Joseph D,Buxbaum [40]
;
Nigel J,Cairns [41]
;
Laura B,Cantwell [7]
;
Chuanhai,Cao [42]
;
Christopher S,Carlson [43]
;
Cynthia M,Carlsson [44]
;
Regina M,Carney [45]
;
Minerva M,Carrasquillo [19]
;
Scott,Chasse [46]
;
Marie-Francoise,Chesselet [47]
;
Nathaniel A,Chin [48]
;
Helena C,Chui [49]
;
Jaeyoon,Chung [6]
;
Suzanne,Craft [50]
;
Paul K,Crane [51]
;
David H,Cribbs [52]
;
Elizabeth A,Crocco [53]
;
Carlos,Cruchaga [54]
;
Michael L,Cuccaro [1]
;
Munro,Cullum [15]
;
Eveleen,Darby [55]
;
Barbara,Davis [56]
;
Philip L,De Jager [57]
;
Charles,DeCarli [58]
;
John,DeToledo [59]
;
Malcolm,Dick [60]
;
Dennis W,Dickson [19]
;
Beth A,Dombroski [7]
;
Rachelle S,Doody [55]
;
Ranjan,Duara [61]
;
NIlüfer,Ertekin-Taner [62]
;
Denis A,Evans [63]
;
Kelley M,Faber [64]
;
Thomas J,Fairchild [65]
;
Kenneth B,Fallon [66]
;
David W,Fardo [67]
;
Martin R,Farlow [68]
;
Victoria,Fernandez-Hernandez [29]
;
Steven,Ferris [69]
;
Robert P,Friedland [70]
;
Tatiana M,Foroud [64]
;
Matthew P,Frosch [71]
;
Brian,Fulton-Howard [72]
;
Douglas R,Galasko [37]
;
Adriana,Gamboa [73]
;
Marla,Gearing [74]
;
Daniel H,Geschwind [47]
;
Bernardino,Ghetti [75]
;
John R,Gilbert [1]
;
Rodney C P,Go [66]
;
Alison M,Goate [76]
;
Thomas J,Grabowski [77]
;
Neill R,Graff-Radford [62]
;
Robert C,Green [78]
;
John H,Growdon [79]
;
Hakon,Hakonarson [80]
;
James,Hall [20]
;
Ronald L,Hamilton [81]
;
Oscar,Harari [82]
;
John,Hardy [83]
;
Lindy E,Harrell [84]
;
Elizabeth,Head [85]
;
Victor W,Henderson [86]
;
Michelle,Hernandez [59]
;
Timothy,Hohman [87]
;
Lawrence S,Honig [88]
;
Ryan M,Huebinger [89]
;
Matthew J,Huentelman [90]
;
Christine M,Hulette [91]
;
Bradley T,Hyman [79]
;
Linda S,Hynan [92]
;
Laura,Ibanez [93]
;
Gail P,Jarvik [94]
;
Suman,Jayadev [95]
;
Lee-Way,Jin [96]
;
Kim,Johnson [59]
;
Leigh,Johnson [97]
;
M Ilyas,Kamboh [98]
;
Anna M,Karydas [36]
;
Mindy J,Katz [99]
;
John S,Kauwe [100]
;
Jeffrey A,Kaye [101]
;
C Dirk,Keene [102]
;
Aisha,Khaleeq [55]
;
Masataka,Kikuchi [12]
;
Ronald,Kim [85]
;
Janice,Knebl [97]
;
Neil W,Kowall [103]
;
Joel H,Kramer [104]
;
Walter A,Kukull [105]
;
Frank M,LaFerla [106]
;
James J,Lah [107]
;
Eric B,Larson [108]
;
Alan,Lerner [2]
;
James B,Leverenz [10]
;
Allan I,Levey [107]
;
Andrew P,Lieberman [109]
;
Richard B,Lipton [99]
;
Mark,Logue [110]
;
Oscar L,Lopez [27]
;
Kathryn L,Lunetta [111]
;
Constantine G,Lyketsos [112]
;
Douglas,Mains [73]
;
Flanagan E,Margaret [113]
;
Daniel C,Marson [84]
;
Eden Rr,Martin [1]
;
Frank,Martiniuk [114]
;
Deborah C,Mash [115]
;
Eliezer,Masliah [116]
;
Paul,Massman [55]
;
Arjun,Masurkar [69]
;
Wayne C,McCormick [51]
;
Susan M,McCurry [117]
;
Andrew N,McDavid [43]
;
Stefan,McDonough [118]
;
Ann C,McKee [119]
;
Marsel,Mesulam [113]
;
Bruce L,Miller [120]
;
Carol A,Miller [121]
;
Joshua W,Miller [96]
;
Thomas J,Montine [122]
;
Edwin S,Monuki [123]
;
John C,Morris [124]
;
Shubhabrata,Mukherjee [51]
;
Amanda J,Myers [53]
;
Trung,Nguyen [125]
;
Thomas,Obisesan [126]
;
Sid,O'Bryant [127]
;
John M,Olichney [128]
;
Marcia,Ory [129]
;
Raymond,Palmer [130]
;
Joseph E,Parisi [131]
;
Henry L,Paulson [132]
;
Valory,Pavlik [55]
;
David,Paydarfar [16]
;
Victoria,Perez [59]
;
Elaine,Peskind [133]
;
Ronald C,Petersen [34]
;
Helen,Petrovitch [134]
;
Aimee,Pierce [52]
;
Marsha,Polk [130]
;
Wayne W,Poon [60]
;
Huntington,Potter [135]
;
Liming,Qu [7]
;
Mary,Quiceno [136]
;
Joseph F,Quinn [101]
;
Ashok,Raj [42]
;
Murray,Raskind [133]
;
Eric M,Reiman [137]
;
Barry,Reisberg [138]
;
Joan S,Reisch [56]
;
John M,Ringman [139]
;
Erik D,Roberson [84]
;
Monica,Rodriguear [55]
;
Ekaterina,Rogaeva [140]
;
Howard J,Rosen [36]
;
Roger N,Rosenberg [125]
;
Donald R,Royall [141]
;
Marwan,Sabbagh [142]
;
A Dessa,Sadovnick [143]
;
Mark A,Sager [144]
;
Mary,Sano [145]
;
Andrew J,Saykin [146]
;
Julie A,Schneider [147]
;
Lon S,Schneider [148]
;
William W,Seeley [36]
;
Susan H,Slifer [4]
;
Scott,Small [3]
;
Amanda G,Smith [42]
;
Janet P,Smith [56]
;
Joshua A,Sonnen [102]
;
Salvatore,Spina [75]
;
Peter St,George-Hyslop [149]
;
Takiyah D,Starks [150]
;
Robert A,Stern [9]
;
Alan B,Stevens [151]
;
Stephen M,Strittmatter [152]
;
David,Sultzer [153]
;
Russell H,Swerdlow [39]
;
Rudolph E,Tanzi [79]
;
Jeffrey L,Tilson [154]
;
John Q,Trojanowski [7]
;
Juan C,Troncoso [155]
;
Magda,Tsolaki [156]
;
Debby W,Tsuang [157]
;
Vivianna M,Van Deerlin [7]
;
Linda J,van Eldik [158]
;
Jeffery M,Vance [1]
;
Badri N,Vardarajan [88]
;
Robert,Vassar [113]
;
Harry V,Vinters [159]
;
Jean-Paul,Vonsattel [88]
;
Sandra,Weintraub [160]
;
Kathleen A,Welsh-Bohmer [161]
;
Patrice L,Whitehead [4]
;
Ellen M,Wijsman [162]
;
Kirk C,Wilhelmsen [46]
;
Benjamin,Williams [163]
;
Jennifer,Williamson [88]
;
Henrik,Wilms [59]
;
Thomas S,Wingo [107]
;
Thomas,Wisniewski [164]
;
Randall L,Woltjer [163]
;
Martin,Woon [31]
;
Clinton B,Wright [165]
;
Chuang-Kuo,Wu [59]
;
Steven G,Younkin [62]
;
Chang-En,Yu [51]
;
Lei,Yu [166]
;
Xiongwei,Zhu [167]
;
Brian W,Kunkle [1]
;
William S,Bush [8]
;
Akinori,Miyashita [12]
;
Goldie S,Byrd [168]
;
Li-San,Wang [7]
;
Lindsay A,Farrer [169]
;
Jonathan L,Haines [8]
;
Richard,Mayeux [88]
;
Margaret A,Pericak-Vance [1]
;
Gerard D,Schellenberg [7]
;
Gyungah R,Jun [170]
;
Christiane,Reitz [171]
;
Adam C,Naj [172]
;
Alzheimer’s Disease Genetics Consortium (ADGC)
作者单位：
Dr. John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA.;The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
[1]
Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
[2]
Taub Institute for Research in Alzheimer's Disease and the Aging Brain, The Gertrude H. Sergievsky Center Department of Neurology, Columbia University, New York, NY, USA.;Department of Neurology, Columbia University, New York, NY, USA.
[3]
The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
[4]
Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
[5]
Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
[6]
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
[7]
Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.;Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.
[8]
Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
[9]
Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USA.
[10]
Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.;Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
[11]
Molecular Genetics Division, Brain Research Institute, Niigata University, Niigata, Japan.
[12]
Sanders-Brown Center on Aging, Department of Epidemiology, College of Public Health, University of Kentucky, Lexington, KY, USA.
[13]
Dr. John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA.
[14]
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
[15]
Department of Neurology, Dell Medical School, University of Texas at Austin, Austin, TX, USA.
[16]
Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
[17]
Department of Neurology, University of Michigan, Ann Arbor, MI, USA.;Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, MI, USA.;Michigan Alzheimer's Disease Center, University of Michigan, Ann Arbor, MI, USA.
[18]
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
[19]
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.
[20]
Departments of Neurology, Radiology, and Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.;Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA.
[21]
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
[22]
Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, WI, USA.;Department of Medicine, University of Wisconsin, Madison, WI, USA.;Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA.
[23]
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.;Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA.;Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
[24]
Taub Institute for Research in Alzheimer's Disease and the Aging Brain, The Gertrude H. Sergievsky Center Department of Neurology, Columbia University, New York, NY, USA.;Department of Neurology, Columbia University, New York, NY, USA.;Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.
[25]
Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, AZ, USA.
[26]
Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh School of Medicine, Pennsylvania, WA, USA.
[27]
National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA.
[28]
Department of Psychiatry and Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA.
[29]
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.;Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
[30]
Department of Psychiatry , University of Texas at Austin/Dell Medical School, Austin, TX, USA.
[31]
VA Puget Sound Health Care System/GRECC, Seattle, WA, USA.;Department of Neurology, University of Washington, Seattle, WA, USA.
[32]
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.;Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
[33]
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
[34]
Swedish Medical Center, Seattle, WA, USA.
[35]
Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
[36]
Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.
[37]
Department of Medicine, Duke University, Durham, NC, USA.
[38]
University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, KS, USA.
[39]
Department of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.;Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.
[40]
Department of Pathology and Immunology, Washington University, St. Louis, MO, USA.
[41]
USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, FL, USA.
[42]
Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
[43]
Department of Medicine, University of Wisconsin, Madison, WI, USA.;Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA.
[44]
Mental Health and Behavioral Science Service, Bruce W. Carter VA Medical Center, Miami, FL, USA.
[45]
Department of Genetics, University of North Carolina Chapel Hill, Chapel Hill, NC, USA.
[46]
Neurogenetics Program, University of California Los Angeles, Los Angeles, CA, USA.
[47]
Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, WI, USA.;Department of Medicine, University of Wisconsin, Madison, WI, USA.
[48]
University of California Los Angeles, University of Southern California, Los Angeles, CA, USA.
[49]
Section of Gerontology and Geriatric Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.
[50]
Department of Medicine, University of Washington, Seattle, WA, USA.
[51]
Department of Neurology, University of California Irvine, Irvine, CA, USA.
[52]
Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.
[53]
NeuroGenomics and Informatics, Washington University, St Louis, MO, USA.;Department of Psychiatry, Washington University in St. Louis, St Louis, MO, USA.
[54]
Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX, USA.
[55]
Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
[56]
Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA.
[57]
Department of Neurology, University of California Davis, Sacramento, CA, USA.
[58]
Departments of Neurology, Pharmacology and Neuroscience, Texas Tech University Health Science Center, Lubbock, TX, USA.
[59]
Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA.
[60]
Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA.
[61]
Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.;Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
[62]
Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
[63]
Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.
[64]
Office of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, TX, USA.
[65]
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
[66]
Sanders-Brown Center on Aging, Department of Biostatistics, College of Public Health, University of Kentucky, Lexington, KY, USA.
[67]
Department of Neurology, Indiana University, Indianapolis, IN, USA.
[68]
Department of Psychiatry, New York University, New York, NY, USA.
[69]
Department of Neurology, University of Louisville School of Medicine, Lousiville, KY, USA.
[70]
C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, MA, USA.
[71]
Department of Neuroscience, Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[72]
Department of Health Behavior and Health Systems, University of North Texas Health Science Center, Fort Worth, TX, USA.;Department of Health Management and Policy, School of Public Health, University of North Texas Health Science Center, Fort Worth, TX, USA.
[73]
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.;Emory Alzheimer's Disease Center, Emory University, Atlanta, GA, USA.
[74]
Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA.
[75]
Department of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
[76]
Department of Neurology, University of Washington, Seattle, WA, USA.;Department of Radiology, University of Washington, Seattle, WA, USA.
[77]
Division of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Division of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Boston, MA, USA.
[78]
Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
[79]
Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.;Division of Human Genetics, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, UK.
[80]
Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, PA, UK.
[81]
Department of Psychiatry, Washington University in St. Louis, St Louis, MO, USA.
[82]
UCL Institute of Neurology, University College London, London, England, USA.;Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, England, USA.
[83]
Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
[84]
Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA, USA.
[85]
Department of Epidemiology and Population Health, Stanford University, Stanford, CA, USA.;Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
[86]
Vanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.;Vanderbilt Genetics Institute, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
[87]
Taub Institute for Research in Alzheimer's Disease and the Aging Brain, The Gertrude H. Sergievsky Center Department of Neurology, Columbia University, New York, NY, USA.
[88]
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
[89]
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
[90]
Department of Pathology, Duke University, Durham, NC, USA.
[91]
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.;Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.;Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
[92]
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.;Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA.
[93]
Department of Genome Sciences, University of Washington, Seattle, WA, USA.;Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA.
[94]
Department of Neurology, University of Washington, Seattle, WA, USA.
[95]
Department of Pathology and Laboratory Medicine, University of California Davis, Sacramento, CA, USA.
[96]
Department of Health Behavior and Health Systems, University of North Texas Health Science Center, Fort Worth, TX, USA.
[97]
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.;Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.;Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA.
[98]
Department of Neurology, Albert Einstein College of Medicine, New York, NY, USA.
[99]
Department of Neuroscience, Brigham Young University, Provo, UT, USA.;Department of Biology, yBrigham Young University, Provo, UT, USA.
[100]
Department of Neurology, Oregon Health and Science University, Portland, OR, USA.;Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
[101]
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
[102]
Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.;Department of Pathology, Boston University, Boston, MA, USA.
[103]
Department of Neuropsychology, University of California San Francisco, San Francisco, CA, USA.
[104]
Department of Epidemiology, University of Washington, Seattle, Seattle, USA.
[105]
Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.
[106]
Department of Neurology, Emory University, Atlanta, GA, USA.
[107]
National Center for PTSD, Boston VA Healthcare System, Boston, MA, USA.
[108]
Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
[109]
Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.;National Center for PTSD at Boston VA Healthcare System, Boston, MA, USA.;Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
[110]
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
[111]
Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.
[112]
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.;Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
[113]
Department of Medicine - Pulmonary, New York University, New York, NY, USA.
[114]
Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.
[115]
Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.;Department of Pathology, University of California San Diego, La Jolla, CA, USA.
[116]
School of Nursing Northwest Research Group on Aging, University of Washington, Seattle, WA, USA.
[117]
Pfizer Worldwide Research and Development, New York, NY, USA.
[118]
Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.;Department of Pathology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
[119]
Weill Institute for Neurosciences, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.
[120]
Department of Pathology, University of Southern California, Los Angeles, CA, USA.
[121]
Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
[122]
Department of Pathology and Laboratory Medicine and Alzheimer's Disease Research Center, University of California Irvine, Irvine, CA, USA.
[123]
Department of Pathology and Immunology, Washington University, St. Louis, MO, USA.;Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, MO, USA.;Department of Neurology, Washington University, St. Louis, MO, USA.;Department of Psychiatry, Washington University School of Medicine, St. Louis Missouri, USA.
[124]
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
[125]
Department of Research Regulatory Compliance, College of Medicine, Howard Unviersity, Washington, DC, USA.
[126]
Institute for Translational Research, University of North Texas Health Science Center, Fort Worth,, TX, USA.
[127]
Center for Mind and Brain and Department of Neurology, University of California Davis, Sacramento, CA, USA.
[128]
Center for Population Health and Aging, Texas AandM University Health Science Center, Lubbock , TX, USA.
[129]
Department of Family and Community Medicine, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.
[130]
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
[131]
Department of Neurology, University of Michigan, Ann Arbor, MI, USA.;Michigan Alzheimer's Disease Center, University of Michigan, Ann Arbor, MI, USA.
[132]
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.
[133]
Pacific Health Research & Education Institute, VA Pacific Islands Healthcare System, Honolulu, HI, USA.
[134]
Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA.
[135]
Department of Internal Medicine and Geriatrics, University of North Texas Health Science Center, Fort Worth, TX, USA.;Department of Medical Education, TCU/UNTHSC School of Medicine, Fort Worth, TX, USA.
[136]
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.;Arizona Alzheimer's Consortium, Phoenix, AZ, Canada.;Banner Alzheimer's Institute, Phoenix, AZ, USA.;Department of Psychiatry, University of Arizona, Phoenix, AZ, USA.
[137]
Department of Psychiatry, New York University, New York, NY, USA.;Alzheimer's Disease Center, New York University, New York, NY, USA.
[138]
Department of Neurology, University of California Los Angeles, Los Angeles, CA, USA.
[139]
Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, ON, Canada.
[140]
Departments of Psychiatry, Medicine, Family and Community Medicine, and the Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health Science Center at San Antonio,, San Antonio, TX, Canada.
[141]
Department of Neurology, Barrow Neurological Institute St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
[142]
Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
[143]
Department of Medicine, University of Wisconsin, Madison, WI, USA.
[144]
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.
[145]
Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.;Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, USA.
[146]
Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.;Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.;Department of Pathology (Neuropathology), Rush University Medical Center, Chicago, IL, USA.
[147]
University of California Los Angeles, University of Southern California, Los Angeles, CA, USA.;Department of Psychiatry, University of Southern California, Los Angeles, CA, USA.
[148]
Cambridge Institute for Medical Research, University of Cambridge, Cambridge, England, USA.;Faculty of Medicine, Department of Medicine (Neurology), University of Toronto, Toronto, ON, USA.
[149]
Maya Angelou Center for Health Equity, Wake Forest School of Medicine, Winston-Salem, NC, USA.;Center for Outreach in Alzheimer's, Aging and Community Health at North Carolina A&T State University, Greensboro, NC, USA.
[150]
Center for Applied Health Research, Baylor Scott & White Health, Temple, TX, USA.;Center for Population Health and Aging, Texas A&M University Health Science Center, Lubbock, TX, USA.;College of Medicine, Texas A&M University Health Science Center, College Station, TX, USA.
[151]
Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT, USA.
[152]
Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA.
[153]
Renaissance Computing Institute, University of North Carolina Chapel Hill, Chapel Hill, NC, USA.
[154]
Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.
[155]
Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Macedonia, USA.
[156]
VA Puget Sound Health Care System/GRECC, Seattle, WA, USA.;Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.
[157]
Sanders-Brown Center on Aging, Department of Neuroscience, College of Medicine, University of Kentucky, Kentucky, OH, USA.
[158]
Department of Neurology, University of California Los Angeles, Los Angeles, CA, USA.;Department of Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, USA.
[159]
Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
[160]
Department of Medicine, Duke University, Durham, NC, USA.;Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
[161]
Department of Genome Sciences, University of Washington, Seattle, WA, USA.;Department of Medicine (Medical Genetics), University of Washington, Seattle, WA, USA.;Department of Biostatistics, University of Washington, Seattle, WA, USA.
[162]
Department of Pathology, Oregon Health and Science University, Portland, OR, USA.
[163]
Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, USA.;Center for Cognitive Neurology and Departments of Neurology and Pathology, New York University Grossman School of Medicine, New York, USA.
[164]
Evelyn F. McKnight Brain Institute, Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.
[165]
Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA.;Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.;Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
[166]
Social Sciences & Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA.
[167]
Department of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
[168]
Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.;Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.;Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.;Department of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.;Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
[169]
Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.;Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.;Department of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
[170]
Department of Neurology, Columbia University, New York, NY, USA.;Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.;Department of Epidemiology, Columbia University, New York, NY, USA.
[171]
Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. adamnaj@pennmedicine.upenn.edu.;Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. adamnaj@pennmedicine.upenn.edu.
[172]
医学主题词
人类(Humans);男(雄)性(Male);阿尔茨海默病(Alzheimer Disease);基因座(Genetic Loci);疾病遗传易感性(Genetic Predisposition to Disease);全基因组关联研究(Genome-Wide Association Study);多态性, 单核苷酸(Polymorphism, Single Nucleotide)
DOI
10.1186/s13059-025-03564-z
PMID
40676597
发布时间
2025-09-22
- 浏览0
Genome biology
Genome biology
210页
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