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Single-cell transcriptomics reveal individual and cooperative effects of trisomy 21 and GATA1s on hematopoiesis.

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第一作者： Kaoru,Takasaki

第一单位： Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

作者： Kaoru,Takasaki ^[1] ; Eric K,Wafula ^[2] ; Jian Meng,Fan ^[3] ; Ying Ting,Sit ^[3] ; Sara S,Kumar ^[3] ; David,Smith ^[2] ; Alyssa,Gagne ^[4] ; Peter A,Gearhart ^[5] ; Deborah L,French ^[6] ; Christopher S,Thom ^[7] ; Stella T,Chou ^[8]

作者单位： Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[1] Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. ^[2] Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. ^[3] Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. ^[4] Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Obstetrics and Gynecology, Pennsylvania Hospital, University of Pennsylvania Health System, Philadelphia, PA, USA. ^[5] Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. ^[6] Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. ^[7] Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address: chous@chop.edu. ^[8]

关键词 Down syndrome GATA1 GATA1s Trisomy 21 hematopoiesis hematopoietic progenitors iPSC lineage priming single-cell RNA sequencing transient abnormal myelopoiesis